Hyperalgesia and allodynia are frequent symptoms of disease and may be useful
adaptations to protect vulnerable tissues. Both may, however, also emerge as diseases in …

Neuro-immune alterations in the peripheral and central nervous system play a role in the
pathophysiology of chronic pain, and non-coding RNAs (ncRNAs)–and microRNAs …

The maintenance of chronic pain states requires the regulation of gene expression, which
relies on an influx of calcium. Calcium influx through neuronal L-type voltage-gated calcium …

L‐type voltage‐gated calcium channels are ubiquitous channels in the CNS. L‐type calcium
channels (LTCs) are mostly post‐synaptic channels regulating neuronal firing and gene …

The orofacial region is a major focus of chronic neuropathic pain conditions characterized by
primary hyperalgesia at the site of injury and secondary hyperalgesia outside the injured …

Paroxysmal depolarization shifts (PDS) have been described by epileptologists for the first
time several decades ago, but controversy still exists to date regarding their role in epilepsy …

Key points L‐type calcium channels in the CNS exist as two subunit forming channels, Cav1.
2 and Cav1. 3, which are involved in short‐and long‐term plasticity. We demonstrate that …

Animal models of pain consist of modeling a pain-like state and measuring the consequent
behavior. The first animal models of neuropathic pain (NP) were developed in rodents with a …

Background We investigated the role of different voltage sensitive calcium channels
expressed at presynaptic afferent terminals in substance P release and on nociceptive …

Neuropathic pain is a complex condition with a huge unmet medical need. Owing to our
incomplete understanding of its perplexing pathology, current therapeutic strategies for …