Increased Chamber Resting Tone Is a Key Determinant of Left Ventricular Diastolic Dysfunction

M Tamargo, P Martínez-Legazpi… - Circulation: Heart …, 2023 - Am Heart Assoc
BACKGROUND: Twitch-independent tension has been demonstrated in cardiomyocytes, but
its role in heart failure (HF) is unclear. We aimed to address twitch-independent tension as a …

Assessing systolic and diastolic reserves in male and female mice

B Coyle-Asbil, EJB Holjak, JP Marrow… - American Journal …, 2023 - journals.physiology.org
Cardiac reserve is a widely used health indicator and prognostic tool. Although it is well
established how to assess cardiac reserve clinically, in preclinical models, it is more …

[PDF][PDF] Improving rigor and reproducibility in cardiovascular research

ML Lindsey, AJ LeBlanc, L Bertrand… - American Journal …, 2023 - journals.physiology.org
Improving Rigor and Reproducibility in Cardiovascular Research 1 Merry L. Lindsey1, Amanda J.
LeBlanc2, Luc Bertrand3, Amy D. B Page 1 Improving Rigor and Reproducibility in …

Does EDPVR Represent Myocardial Tissue Stiffness? Toward a Better Definition

RR Mehdi, EA Mendiola, V Naeini… - arXiv preprint arXiv …, 2024 - arxiv.org
Accurate assessment of myocardial tissue stiffness is pivotal for the diagnosis and prognosis
of heart diseases. Left ventricular diastolic stiffness ($\beta $) obtained from the end-diastolic …

Can Rapid Atrial Pacing Mimic Exercise in Diagnosing Heart Failure With Preserved Ejection Fraction?

SP Kutalek, A Gupta - American Journal of Cardiology, 2024 - ajconline.org
Heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) often co-exist
and are interdependent of one another. 1, 2 HFpEF is often underdiagnosed in patients with …

A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models

G Numata, E Takimoto - JoVE (Journal of Visualized Experiments), 2023 - jove.com
Heart failure with preserved ejection fraction (HFpEF) is a condition characterized by
diastolic dysfunction and exercise intolerance. While exercise-stressed hemodynamic tests …

Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach (Video)| JoVE

G Numata, E Takimoto - JoVE (Journal of Visualized Experiments), 2023 - jove.com
Heart failure with preserved ejection fraction (HFpEF) is a condition characterized by
diastolic dysfunction and exercise intolerance. While exercise-stressed hemodynamic tests …