Even with the assistance of many cellular factors, a significant fraction of newly synthesized
proteins ends up misfolded. Cells evolved protein quality control systems to ensure that …

Membrane-bound and soluble proteins of the secretory pathway are commonly glycosylated
in the endoplasmic reticulum. These adducts have many biological functions, including …

The secretory pathway is responsible for the synthesis, folding, and delivery of a diverse
array of cellular proteins. Secretory protein synthesis begins in the endoplasmic reticulum …

Eukaryotic cells activate the unfolded-protein response (UPR) upon endoplasmic reticulum
(ER) stress, where the stress is assumed to be the accumulation of unfolded proteins in the …

Protein secretion is an essential process for living organisms. In eukaryotes, this
encompasses numerous steps mediated by several hundred cellular proteins. The core …

Numerous nascent proteins undergo folding and maturation within the luminal and
membrane compartments of the endoplasmic reticulum (ER). Despite the presence of …

Background The quality of proteins destined for the secretory pathway is ensured by two
distinct mechanisms in the endoplasmic reticulum (ER): productive folding of newly …

The metazoan O-mannose (O-Man) glycoproteome is largely unknown. It has been shown
that up to 30% of brain O-glycans are of the O-Man type, but essentially only alpha …

To maximize therapeutic effects and minimize unwanted effects, the interest in drug targeting
to the endoplasmic reticulum (ER) or Golgi apparatus (GA) has been recently growing …

Background: Protein O-mannosylation is a vital type of glycosylation that is conserved
among fungi, animals, and humans. It is initiated in the endoplasmic reticulum (ER) where …