Aminoglycosides are a group of antibiotics used since the 1940s to primarily treat a broad
spectrum of bacterial infections. The primary resistance mechanism against these antibiotics …

Hereunder, we highlight bacterial membrane anionic lipids as attractive targets in the design
of antibacterial drugs which can be effective against both Gram-positive and Gram-negative …

The rise and emergence of resistance to antifungal drugs by diverse pathogenic fungal
strains have resulted in an increase in demand for new antifungal agents. Various …

In the recent past, prevalence of life threatening fungal diseases have increased rapidly in
immune-compromised cases such as acquired immunodeficiency syndrome (AIDS), cancer …

A systematic analysis of all synthetic and chemoenzymatic methodologies for the
preparation of aminoglycosides for a variety of applications (therapeutic and agricultural) …

The burnettramic acids are a new class of antibiotics from an Australian fungus Aspergillus
burnettii. The rare bolaamphiphilic scaffold consists of β-d-mannose linked to a …

Fungal infections directly affect millions of people each year. In addition to the invasive
fungal infections of humans, the plants and animals that comprise our primary food source …

Cationic amphiphiles derived from aminoglycosides (AGs) have been shown to exhibit
enhanced antimicrobial activity. Through the attachment of hydrophobic residues such as …

Deoxystreptamine (2DOS) is the unique chemically stable aminocyclitol scaffold of clinically
important aminoglycoside antibiotics such as neomycin, kanamycin, and gentamicin, which …

Since the discovery of the first aminoglycoside (AG), streptomycin, in 1943, these broad-
spectrum antibiotics have been extensively used for the treatment of Gram-negative and …