The biology and functional importance of MAIT cells

DI Godfrey, HF Koay, J McCluskey, NA Gherardin - Nature immunology, 2019 - nature.com
In recent years, a population of unconventional T cells called 'mucosal-associated invariant
T cells'(MAIT cells) has captured the attention of immunologists and clinicians due to their …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2021 - Wiley Online Library
The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

[HTML][HTML] Tissue adaptation and clonal segregation of human memory T cells in barrier sites

MML Poon, DP Caron, Z Wang, SB Wells, D Chen… - Nature …, 2023 - nature.com
T lymphocytes migrate to barrier sites after exposure to pathogens, providing localized
immunity and long-term protection. Here, we obtained blood and tissues from human organ …

[HTML][HTML] T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection

M Musvosvi, H Huang, C Wang, Q Xia, V Rozot… - Nature Medicine, 2023 - nature.com
Antigen-specific, MHC-restricted αβ T cells are necessary for protective immunity against
Mycobacterium tuberculosis, but the ability to broadly study these responses has been …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2019 - Wiley Online Library
These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

COVID‐19 and comorbidities: A role for dipeptidyl peptidase 4 (DPP4) in disease severity?

MF Bassendine, SH Bridge, GW McCaughan… - Journal of …, 2020 - Wiley Online Library
Abstract The coronavirus disease 2019 (COVID‐19) pandemic is caused by a novel
betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), similar …

Human blood MAIT cell subsets defined using MR1 tetramers

NA Gherardin, MNT Souter, HF Koay… - Immunology and cell …, 2018 - Wiley Online Library
Mucosal‐associated invariant T (MAIT) cells represent up to 10% of circulating human T
cells. They are usually defined using combinations of non‐lineage‐specific (surrogate) …

Cut to the chase: a review of CD26/dipeptidyl peptidase-4's (DPP4) entanglement in the immune system

C Klemann, L Wagner, M Stephan… - Clinical & …, 2016 - academic.oup.com
Summary CD26/DPP4 (dipeptidyl peptidase 4/DP4/DPPIV) is a surface T cell activation
antigen and has been shown to have DPP4 enzymatic activity, cleaving-off amino-terminal …

[HTML][HTML] Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1

HC Jeffery, B Van Wilgenburg, A Kurioka, K Parekh… - Journal of …, 2016 - Elsevier
Background & Aims Mucosal-Associated Invariant T (MAIT) cells are innate-like T cells
characterised by the invariant TCR-chain, Vα7. 2-Jα33, and are restricted by MR1, which …

Accelerating research and development of new vaccines against tuberculosis: a global roadmap

F Cobelens, RK Suri, M Helinski… - The Lancet Infectious …, 2022 - thelancet.com
To eliminate tuberculosis globally, a new, effective, and affordable vaccine is urgently
needed, particularly for use in adults and adolescents in low-income and middle-income …