Sex differences in heart failure

CSP Lam, C Arnott, AL Beale… - European heart …, 2019 - academic.oup.com
The overall lifetime risk of heart failure (HF) is similar between men and women, however,
there are marked sex differences in the landscape of this condition that are both important …

Research priorities for heart failure with preserved ejection fraction: national heart, lung, and blood institute working group summary

SJ Shah, BA Borlaug, DW Kitzman, AD McCulloch… - Circulation, 2020 - Am Heart Assoc
Heart failure with preserved ejection fraction (HFpEF), a major public health problem that is
rising in prevalence, is associated with high morbidity and mortality and is considered to be …

Obesity and heart failure with preserved ejection fraction: new insights and pathophysiological targets

BA Borlaug, MD Jensen, DW Kitzman… - Cardiovascular …, 2022 - academic.oup.com
Obesity and heart failure with preserved ejection fraction (HFpEF) represent two
intermingling epidemics driving perhaps the greatest unmet health problem in …

Evidence supporting the existence of a distinct obese phenotype of heart failure with preserved ejection fraction

M Obokata, YNV Reddy, SV Pislaru, V Melenovsky… - Circulation, 2017 - Am Heart Assoc
Background: Heart failure (HF) with preserved ejection fraction (HFpEF) is a heterogeneous
syndrome. Phenotyping patients into pathophysiologically homogeneous groups may …

Effects of sacubitril-valsartan versus valsartan in women compared with men with heart failure and preserved ejection fraction: insights from PARAGON-HF

JJV McMurray, AM Jackson, CSP Lam, MM Redfield… - Circulation, 2020 - Am Heart Assoc
Background: Unlike heart failure with reduced ejection fraction, there is no approved
treatment for heart failure with preserved ejection fraction, the predominant phenotype in …

Reference ranges for NT-proBNP (N-terminal pro-B-type natriuretic peptide) and risk factors for higher NT-proBNP concentrations in a large general population cohort

P Welsh, RT Campbell, L Mooney… - Circulation: Heart …, 2022 - Am Heart Assoc
Background: Demographic differences in expected NT-proBNP (N-terminal pro-B-type
natriuretic peptide) concentration are not well established. We aimed to establish reference …

Sex‐specific cardiovascular structure and function in heart failure with preserved ejection fraction

M Gori, CSP Lam, DK Gupta… - European journal of …, 2014 - Wiley Online Library
Aims Women are more likely to develop heart failure with preserved ejection fraction
(HFpEF) than men. We studied the relationship between sex and cardiovascular structure …

Novel biomarkers of cardiovascular disease: applications in clinical practice

MN Lyngbakken, PL Myhre, H Røsjø… - Critical reviews in …, 2019 - Taylor & Francis
Measurement of biomarkers has revolutionized the work-up of patients with suspected
cardiovascular disease. The most widely used contemporary cardiovascular biomarkers are …

Role of estrogen in diastolic dysfunction

Z Zhao, H Wang, JA Jessup… - American Journal …, 2014 - journals.physiology.org
The prevalence of left ventricular diastolic dysfunction (LVDD) sharply increases in women
after menopause and may lead to heart failure. While evidence suggests that estrogens …

Menopause-Related Estrogen Decrease and the Pathogenesis of HFpEF: JACC Review Topic of the Week

AR Sabbatini, G Kararigas - Journal of the American College of Cardiology, 2020 - jacc.org
Heart failure (HF) is a complex condition affecting> 40 million people worldwide. It is defined
by failure of the heart to pump (HF with reduced ejection fraction) or by the failure of the …