Potential of targeting host cell calcium dynamics to curtail SARS-CoV-2 infection and COVID-19 pathogenesis

F Sultan, K Ahuja, RK Motiani - Cell calcium, 2022 - Elsevier
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection and
associated coronavirus disease 2019 (COVID-19) has severely impacted human well-being …

Calcium‐dependent antimicrobials: Nature‐inspired materials and designs

Z Wang, Y Zeng, Z Ahmed, H Qin, IA Bhatti… - Exploration, 2024 - Wiley Online Library
Bacterial infection remains a major complication answering for the failures of various
implantable medical devices. Tremendous extraordinary advances have been published in …

SARS-CoV-2 spike fusion peptide trans interaction with phosphatidylserine lipid triggers membrane fusion for viral entry

P Singh, P Pahari, S Mukherjee, S Karmakar… - Mbio, 2024 - journals.asm.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike is the fusion machine
for host cell entry. Still, the mechanism by which spike protein interacts with the target lipid …

Modeling identifies variability in SARS-CoV-2 uptake and eclipse phase by infected cells as principal drivers of extreme variability in nasal viral load in the 48 h post …

J Pearson, T Wessler, A Chen, RC Boucher… - Journal of Theoretical …, 2023 - Elsevier
The SARS-CoV-2 coronavirus continues to evolve with scores of mutations of the spike,
membrane, envelope, and nucleocapsid structural proteins that impact pathogenesis …

Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning

R Lei, E Qing, A Odle, M Yuan… - Nature …, 2024 - nature.com
The fusion peptide of SARS-CoV-2 spike protein is functionally important for membrane
fusion during virus entry and is part of a broadly neutralizing epitope. However, sequence …

Peimine inhibits variants of SARS‐CoV‐2 cell entry via blocking the interaction between viral spike protein and ACE2

WJ Wang, Y Chen, WC Su, YY Liu… - Journal of Food …, 2022 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) is caused by the novel severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Several vaccines against SARS‐CoV‐2 …

Fusion assays for screening of fusion inhibitors targeting SARS-CoV-2 entry and syncytia formation

SW Chan - Frontiers in Pharmacology, 2022 - frontiersin.org
Virus fusion process is evolutionarily conserved and provides a promising pan-viral target.
Cell-cell fusion leads to syncytial formation and has implications in pathogenesis, virus …

[HTML][HTML] Sulfated liposome-based artificial cell membrane glycocalyx nanodecoys for coronavirus inactivation by membrane fusion

X Li, N Cheng, D Shi, Y Li, C Li, M Zhu, Q Jin, Z Wu… - Bioactive Materials, 2024 - Elsevier
As a broad-spectrum antiviral nanoparticle, the cell membrane nanodecoy is a promising
strategy for preventing viral infections. However, most of the cell membrane nanodecoys can …

Cellular endosomal potassium ion flux regulates arenavirus uncoating during virus entry

AB Shaw, HN Tse, O Byford, G Plahe, A Moon-Walker… - Mbio, 2024 - Am Soc Microbiol
Lymphocytic choriomeningitis virus (LCMV) is an enveloped and segmented negative-sense
RNA virus classified within the Arenaviridae family of the Bunyavirales order. LCMV is …

Serum Calcium and Magnesium Levels in Patients with Type 2 Diabetes and COVID-19 Infection Requiring Hospitalization—Correlations with Various Parameters

PA Reștea, Ș Tigan, L Fritea, LG Vicaș, E Marian… - Microbiology …, 2024 - mdpi.com
The purpose of this research was to analyze the impact of SARS-CoV-2 infection on ionic
calcium, total calcium and serum magnesium upon hospital admission, taking into account …