The canonical Wnt/β-catenin signaling plays a fundamental role in regulating embryonic
development, injury repair and the pathogenesis of human diseases. In vertebrates, low …

Parathyroid hormone (PTH) plays a pivotal role in maintaining calcium homeostasis, largely
by modulating bone remodeling processes. Its effects on bone are notably dependent on the …

LRP6 is a member of the low-density lipoprotein receptor superfamily of cell-surface
receptors. It is required for the activation of the Wnt/β-catenin signalling pathway. LRP6 is …

Targeting specific molecular drivers of tumor growth is a key approach in cancer therapy.
Among these targets, the low-density lipoprotein receptor-related protein 6 (LRP6), a vital …

Hepatocyte is a hub for cholesterol metabolism. Augmented synthesis of cholesterol in the
liver is associated with hypercholesterolemia and contributes to the pathogenesis of a host …

We have previously shown that parathyroid hormone (PTH) induces the phosphorylation of
the DNA-binding protein Nascent polypeptide associated complex And Coregulator alpha …

The ubiquitin-proteasome system regulates biological processes in normal and diseased
states. Recent investigations have focused on ubiquitin-dependent modifications and their …

The transcriptional cofactor nascent polypeptide-associated complex and co-regulator α
(NACA) regulates osteoblast maturation and activity. NACA functions, at least in part, by …

Abstract Intermittent administration of PTH (1–34) has a profound osteoanabolic effect on the
skeleton. At the cellular level, osteoblasts and osteocytes are two crucial cell types that …

The transcription factor NFATc1 and its binding partner AP-1 (a complex containing c-fos
and c-Jun) play a central role in osteoclast differentiation. NFATc1 and AP-1 promote the …