In their natural environment, plants are part of a rich ecosystem including numerous and
diverse microorganisms in the soil. It has been long recognized that some of these microbes …

Polystyrene (PS) has brought in vitro cell culture from its humble beginnings to the modern
era, propelling dozens of research fields along the way. This review discusses the …

Reconstructed microbial metabolic networks facilitate a mechanistic description of the
genotype–phenotype relationship through the deployment of constraint-based …

The availability and utility of genome‐scale metabolic reconstructions have exploded since
the first genome‐scale reconstruction was published a decade ago. Reconstructions have …

Carbon fixation is the process by which CO2 is incorporated into organic compounds. In
modern agriculture in which water, light, and nutrients can be abundant, carbon fixation …

Robustness, the ability to maintain performance in the face of perturbations and uncertainty,
is a long-recognized key property of living systems. Owing to intimate links to cellular …

Microbial cells operate under governing constraints that limit their range of possible
functions. With the availability of annotated genome sequences, it has become possible to …

The manner in which microorganisms utilize their metabolic processes can be predicted
using constraint-based analysis of genome-scale metabolic networks. Herein, we present …

Genome sequences are now available that enable us to determine the biological
components that make up a cell or an organism. The discipline of systems biology examines …

Metabolomics is the comprehensive study of small molecule metabolites in biological
systems. By assaying and analyzing thousands of metabolites in biological samples, it …