Globular PDZ domains typically serve as protein–protein interaction modules that regulate a
wide variety of cellular functions via recognition of short linear motifs (SLiMs). Often, PDZ …

Two alternative strategies are commonly used to study protein–protein interactions (PPIs)
and to engineer protein-based inhibitors. In one approach, binders are selected …

Abstract PDZ (PSD-95/Discs-large/Z O1) domains are interaction modules that typically bind
to specific C-terminal sequences of partner proteins and assemble signaling complexes in …

Mutations in the hydrophobic interior of proteins are generally thought to weaken the
interactions only in their immediate neighborhood. This forms the basis of protein …

Understanding the extent to which information is transmitted through the intramolecular
interaction network of proteins upon a perturbation, that is, an allosteric effect, has long …

The PDZ domain (PSD95-Discs large-ZO1) is a widespread modular domain present in the
living organisms. A prevalent function in the PDZ family is to serve as scaffolding and …

The molecular interactions between macrophage colony-stimulating factor (M-CSF) and the
tyrosine kinase receptor c-FMS play a key role in the immune response, bone metabolism …

Targeted inhibition of misregulated protein–protein interactions (PPIs) has been a promising
area of investigation in drug discovery and development for human diseases. However …

The E6 protein from human papillomavirus (HPV) plays an important role during productive
infection and is a potential drug target. We have previously designed a high affinity bivalent …

Molecular recognition is critical for the fidelity of signal transduction in biology. Conversely,
the disruption of protein-protein interactions can lead to disease. Thus, comprehension of …