The primary cilium is a hair-like surface-exposed organelle of the eukaryotic cell that
decodes a variety of signals—such as odorants, light and Hedgehog morphogens—by …

Primary cilia are small, antenna-like organelles that detect and transduce chemical and
mechanical cues in the extracellular environment, regulating cell behavior and, in turn …

Shear stress generated by urinary fluid flow is an important regulator of renal function. Its
dysregulation is observed in various chronic and acute kidney diseases. Previously, we …

Autosomal dominant polycystic kidney disease (ADPKD) affects an estimated 1 in 1,000
people and slowly progresses to end-stage renal disease (ESRD) in about half of these …

Nephronophthisis (NPH) is an autosomal recessive ciliopathy and a major cause of end-
stage renal disease in children. The main forms, juvenile and adult NPH, are characterized …

The primary cilium has gone from being a vestigial organelle to a crucial signaling hub of
growing interest given the association between a group of human disorders, collectively …

Inactivation of the tumor suppressor von Hippel–Lindau (VHL) gene is a key event in
hereditary and sporadic clear cell renal cell carcinomas (ccRCC). The mechanistic target of …

The primary cilium is a nexus for cell signaling and relies on specific protein trafficking for
function. The tubby family protein TULP3 transports integral membrane proteins into cilia …

Background Mutations affecting cilia proteins have an established role in renal cyst
formation. In mice, the rate of cystogenesis is influenced by the age at which cilia dysfunction …

The transcription factor NRF2 plays a key role in the protection against environmental stress
and maintaining cellular homeostasis. The acetyltransferase p300 is a known component of …