Thermal runaway in the semi-batch reactors (SBRs) involving exothermic reaction can have
serious consequences and the primary driver of process design in the SBRs is economic …

In this work a summary of safety assessments based on a concept of boundary diagrams
safety criterion (BDSC) is given and adapted for liquid phase homogeneous reactions …

In this work the general Ψ number criterion for the safe operation of semibatch runaway
reactions has been applied to the optimization of a nitration process of primary importance in …

The maximum temperature of a synthesis reaction (MTSR) is an important criterion for
process risk assessment and reactor design. In this paper, the variation of the dimensionless …

In pharmaceutical and fine chemical industries, fast and strongly exothermic reactions are
often carried out in semibatch reactors (SBRs) to better control the heat evolution by the …

It is well-known that, for certain values of the operative parameters influencing the dynamic
behavior of a chemical reactor, a phenomenon known as thermal runaway (that is, a loss of …

A number of newly developed exothermic reactions of the fine-chemical industry can be
safely tested at the industrial scale in an existing batch reactor since they cannot lead to …

In the fine chemical and pharmaceutical industries, plants are normally operated on a
discontinuous multipurpose logic, according to which the same reactor is used for different …

To obtain thermally safe operating conditions for kinetically controlled liquid-liquid reactions
occurring in isoperibolic semibatch reactors (SBRs), an extreme scenario in which the …

It is common that diffusion controlled liquid–liquid heterogeneous reactions are performed in
isoperibolic semibatch reactors (SBRs) in chemical and pharmaceutical industries. In this …