Noradrenergic and cholinergic systems are among the most vulnerable brain systems in
neuropsychiatric diseases of ageing, including Alzheimer's disease, Parkinson's disease …

Background: Identifying the characteristics of behavioral and psychological symptoms of
dementia (BPSD) associated with different dementia types may be a promising strategy to …

At present, no research criteria exist for the diagnosis of prodromal behavioural variant
frontotemporal dementia (bvFTD), though early detection is of high research importance …

Frontotemporal dementia is clinically and neuropathologically heterogeneous, but
neuroinflammation, atrophy and cognitive impairment occur in all of its principal syndromes …

Objective Synaptic loss is an early feature of neurodegenerative disease models, and is
severe in post mortem clinical studies, including frontotemporal dementia. Positron emission …

Background Dysfunction of the locus coeruleus-noradrenergic system occurs early in
Alzheimer's disease, contributing to cognitive and neuropsychiatric symptoms in some …

The presymptomatic stages of frontotemporal dementia (FTD) are still poorly defined and
encompass a long accrual of progressive biological (preclinical) and then clinical …

Whilst initial anatomical studies of frontotemporal dementia focussed on cortical
involvement, the relevance of subcortical structures to the pathophysiology of frontotemporal …

While frontotemporal dementia has been considered a neurodegenerative disease that
starts in mid-life or later, it is now clearly established that cortical and subcortical volume loss …

Senile depression (SD) is a heterogeneous syndrome. Several clinical profiles are more
likely to appear in SD than in early‐life depression, but it remains unclear whether the …