A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …

The Blood–brain barrier (BBB), present at the level of the endothelium of cerebral blood
vessels, selectively restricts the blood-to-brain paracellular diffusion of compounds; it is …

The central nervous system (CNS) is tightly sealed from the changeable milieu of blood by
the blood–brain barrier (BBB) and the blood–cerebrospinal fluid (CSF) barrier (BCSFB) …

1. The blood–brain barrier is essential for the maintenance and regulation of the neural
microenvironment. The main characteristic features of blood–brain barrier endothelial cells …

Junctional structures maintain the integrity of the endothelium. Recent studies have shown
that, as well as promoting cell–cell adhesion, junctions might transfer intracellular signals …

The RAS oncogenes were identified almost 20 years ago. Since then, we have learnt that
they are members of a large family of small GTPases that bind GTP and hydrolyse it to GDP …

Abstract Intercellular adhesion molecule-1 (ICAM-1; CD54) is a 90 kDa member of the
immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of …

Brain endothelial cells are unique among endothelial cells in that they express apical
junctional complexes, including tight junctions, which quite resemble epithelial tight …

The shuttling of leukocytes between the bloodstream and interstitial tissues involves different
locomotion strategies that are governed by locally presented soluble and cell-bound signals …

The structure and function of the barrier layers restricting the free diffusion of substances
between the central nervous system (brain and spinal cord) and the systemic circulation is of …