Background: Central nervous system (CNS) complications are among the most common,
devastating sequelae of sickle cell disease (SCD) occurring throughout the lifespan …

Sickle cell anemia is a unique disease dominated by hemolytic anemia and vaso-occlusive
events. The latter trigger a version of ischemia/reperfusion (I/R) pathobiology that is singular …

Hemolysis and accumulation of cell-free hemoglobin (Hb) in the circulation or in confined
tissue compartments such as the subarachnoid space is an important driver of disease …

Background Sickle cell disease is one of the commonest severe monogenic disorders in the
world, due to the inheritance of two abnormal haemoglobin (beta globin) genes. Sickle cell …

Cerebral infarction is a common complication of sickle cell disease and may manifest as
overt stroke or cognitive impairment associated with “silent” cerebral infarction on magnetic …

Sickle cell anemia (SCA) is a genetic disease caused by the homozygosity of the HBB: c.
20A> T mutation, which results in the production of hemoglobin S (HbS). In hypoxic …

It is well-established that patients with sickle cell disease (SCD) are at substantial risk of
neurological complications, including overt and silent stroke, microstructural injury, and …

Patients with hematological diseases often experience cerebrovascular complications
including ischemic stroke, intracerebral and subarachnoid hemorrhage, microbleeds …

Background and purpose Silent cerebral infarcts (SCIs) are the most common neurological
complication in children and adults with sickle cell disease (SCD). In this systematic review …

Chronic transfusion therapy (CTT) prevents stroke in selected patients with sickle cell
anemia (SCA). We have shown that CTT mitigates signatures of cerebral metabolic stress …