[HTML][HTML] Recent developments of nanostructures for the ocular delivery of natural compounds

MS Razavi, P Ebrahimnejad, Y Fatahi… - Frontiers in …, 2022 - frontiersin.org
Ocular disorders comprising various diseases of the anterior and posterior segments are
considered as the main reasons for blindness. Natural products have been identified as …

Prodrugs and nanomicelles to overcome ocular barriers for drug penetration

V Gote, M Ansong, D Pal - Expert Opinion on Drug Metabolism & …, 2020 - Taylor & Francis
Introduction Ocular barriers hinder drug delivery and reduce drug bioavailability. This article
focuses on enhancing drug absorption across the corneal and conjunctival epithelium. Both …

A long-acting curcumin nanoparticle/in situ hydrogel composite for the treatment of uveal melanoma

L Xie, W Yue, K Ibrahim, J Shen - Pharmaceutics, 2021 - mdpi.com
Uveal melanoma (UM) is the most common primary intraocular tumor in adults with high
mortality. In order to improve prognosis and survival of UM patients, it is critical to inhibit …

Therapeutic approaches for age-related macular degeneration

RM Galindo-Camacho, C Blanco-Llamero… - International journal of …, 2022 - mdpi.com
Damage to the retinal pigment epithelium, Bruch's membrane and/or tissues underlying
macula is known to increase the risk of age-related macular degeneration (AMD). AMD is …

Discovering the potential of natural antioxidants in age-related macular degeneration: a review

KH Wong, HY Nam, SY Lew, M Naidu, P David… - Pharmaceuticals, 2022 - mdpi.com
Age-related macular degeneration (AMD) is a multifactorial disease associated with
anatomical changes in the inner retina. Despite tremendous advances in clinical care, there …

Recent advances in intraocular and novel drug delivery systems for the treatment of diabetic retinopathy

DS Sharma, S Wadhwa, M Gulati… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: Diabetic retinopathy (DR) is associated with damage to the retinal blood
vessels that lead eventually to vision loss. The existing treatments of DR are invasive …

Emerging innovations in nano-enabled therapy against age-related macular degeneration: A paradigm shift

SK Dubey, R Pradhan, S Hejmady, G Singhvi… - International Journal of …, 2021 - Elsevier
Age-related macular degeneration (AMD), a degenerative eye disease, is the major cause of
irreversible loss of vision among individuals aged 50 and older. Both genetic and …

Medicinal plants and natural products as neuroprotective agents in age-related macular degeneration

F Bosch-Morell, V Villagrasa, T Ortega… - Neural Regeneration …, 2020 - journals.lww.com
The retina may suffer neurodegenerative damages, as other tissues of the central nervous
system do, and serious eye diseases may develop. One of them is age-related macular …

Nanomedicine and drug delivery to the retina: Current status and implications for gene therapy

M Tawfik, F Chen, JL Goldberg, BA Sabel - … -schmiedeberg's Archives of …, 2022 - Springer
Blindness affects more than 60 million people worldwide. Retinal disorders, including age-
related macular degeneration (AMD), diabetic retinopathy (DR), and glaucoma, are the …

Preparation and in vitro/in vivo evaluations of novel ocular micelle formulations of hesperetin with glycyrrhizin as a nanocarrier

F Zhang, H Chen, J Lan, K Song, X Wu - Experimental eye research, 2021 - Elsevier
The purpose of this study was to explore the potential of formulating hesperetin into an
ophthalmic solution with dipotassium glycyrrhizinate (DG) as a micelle nanocarrier. A DG …