5-methylcytosine (m 5 C) post-transcriptional modifications affect the maturation, stability,
and translation of the mRNA molecule. These modifications play an important role in many …

The precise mapping and quantification of the numerous RNA modifications that are present
in tRNAs, rRNAs, ncRNAs/miRNAs, and mRNAs remain a major challenge and a top priority …

The identification of readers, an important class of proteins that recognize modified residues
at specific sites, is essential to uncover the biological roles of post-translational …

RNA modification C 2-methyladenosine (m2A) exists in both rRNA and tRNA of Escherichia
coli (E. coli), installed by the methyltransferase RlmN using a radical-S-adenosylmethionine …

Internal modifications of mRNA have emerged as widespread and versatile regulatory
mechanism to control gene expression at the post-transcriptional level. Most of these …

Abstract Methyl-5-uridine (m5U) is one the most abundant non-canonical bases present in
cellular RNA, and in yeast is found at position U54 of tRNAs where modification is catalysed …

Bacteria possess elaborate systems to manage reactive oxygen and nitrogen species (ROS)
arising from exposure to the mammalian immune system and environmental stresses. Here …

RNA methylation has emerged as a dynamic regulatory mechanism that impacts gene
expression and protein synthesis. Among the known RNA methylation modifications, N6 …

The family of radical SAM RNA-methylating enzymes comprises a large group of proteins
that contains only a few functionally characterized members. Several enzymes in this family …

RNA-nucleoprotein (RNP) complexes are pivotal to the regulation of gene expression.
These multiprotein, multifunctional complexes act as scaffolds, as molecular platforms, as …