Synthesis and biological activity of naturally occurring α-glucosidase inhibitors

DJ Wardrop, SL Waidyarachchi - Natural Product Reports, 2010 - pubs.rsc.org
Covering: 2005 to the end of 2009 In addition to their clinical importance in the treatment of
type II diabetes, α-glucosidase inhibitors have attracted considerable attention from the …

Macrocyclization Reactions at High Concentration (≥ 0.2 M): The Role of Catalysis

F Garnes-Portolés, A Leyva-Pérez - ACS Catalysis, 2023 - ACS Publications
The synthesis of macrocycles is fundamental to obtain useful quantities of this unique family
of organic compounds. However, most current syntheses still require highly diluted …

Alkynes as a versatile platform for construction of chemical molecular complexity and realization of molecular 3D printing

KI Galkin, VP Ananikov - Russian Chemical Reviews, 2016 - iopscience.iop.org
The current level of scientific and technological development requires the formation of
general tools and techniques. One of the most versatile technologies is 3D printing, which …

Ni-catalyzed enantioselective dialkyl carbinol synthesis via decarboxylative cross-coupling: development, scope, and applications

Y Gao, B Zhang, L Levy, HJ Zhang, C He… - Journal of the …, 2022 - ACS Publications
The first enantioselective decarboxylative Negishi-type alkylations of α-oxy carboxylic acids
are reported via the intermediacy of redox-active esters (RAEs). This transformation enables …

Saturated hydroxy fatty acids exhibit a cell growth inhibitory activity and suppress the cytokine-induced β-cell apoptosis

MG Kokotou, AC Kokotos, D Gkikas… - Journal of Medicinal …, 2020 - ACS Publications
The field of bioactive lipids is ever expanding with discoveries of novel lipid molecules that
promote human health. Adopting a lipidomic-assisted approach, two new families of …

Synthesis and enzymatic evaluation of ketose phosphonates: the interplay between mutarotation, monofluorination and acidity

SM Forget, D Bhattasali, VC Hart, TS Cameron… - Chemical …, 2012 - pubs.rsc.org
Ketose-phosphonates may adopt open chain, or α-or β-furanosyl, or α-or β-pyranosyl
configurational isomers in aqueous solution. An HPLC and NMR analysis of a series of …

Asymmetric Synthesis of Saturated and Unsaturated Hydroxy Fatty Acids (HFAs) and Study of Their Antiproliferative Activity

OG Mountanea, C Mantzourani, D Gkikas, PK Politis… - Biomolecules, 2024 - mdpi.com
Hydroxy fatty acids (HFAs) constitute a class of lipids, distinguished by the presence of a
hydroxyl on a long aliphatic chain. This study aims to expand our insights into HFA …

l-Threonine-catalysed asymmetric α-hydroxymethylation of cyclohexanone: application to the synthesis of pharmaceutical compounds and natural products

A Chen, J Xu, W Chiang, CLL Chai - Tetrahedron, 2010 - Elsevier
l-Threonine has been found to be an efficient catalyst for the asymmetric α-
hydroxymethylation of cyclohexanone with formalin. Reducing the amount of water in the …

Total Synthesis of the Proposed Structure of Penasulfate A: l-Arabinose as a Source of Chirality

Y Gao, Z Cao, Q Zhang, R Guo, F Ding… - Journal of natural …, 2019 - ACS Publications
The total synthesis of putative penasulfate A was effectively achieved by a convergent
strategy with a longest linear sequence of 14 steps and overall yield of 8.6%. The highlights …

Алкины в роли универсальной химической платформы для построения объектов высокой молекулярной сложности и реализации молекулярной 3D-печати

КИ Галкин, ВП Анаников - Успехи химии, 2016 - elibrary.ru
Современный уровень научно-технического развития требует создания
универсальных инструментов и методов. Одной из наиболее универсальных …