Personalized medicine tailors therapies, disease prevention, and health maintenance to the
individual, with pharmacogenomics serving as a key tool to improve outcomes and prevent …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Objective: This review consists of three parts, representing three different possibilities of
interactions between cannabinoid receptor ligands of both exogenous and endogenous …

The liver is necessary for survival. Its strategic localisation, blood flow and prominent role in
the metabolism of xenobiotics render this organ particularly susceptible to injury by …

Numerous members of the cytochrome P450 (CYP) superfamily are induced after exposure
to a variety of xenobiotics in human liver. We have gained considerable mechanistic insights …

Pregnane X receptor (PXR) is a major transcription factor regulating the inducible
expression of a variety of transporters and drug-metabolizing enzymes, including CYP3A4 …

Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease in the
Western population. We investigated the association of nonalcoholic fatty liver disease …

Single-cell RNA-seq reveals the role of pathogenic cell populations in development and
progression of chronic diseases. In order to expand our knowledge on cellular …

In vivo enzyme levels are governed by the rates of de novo enzyme synthesis and
degradation. A current lack of consensus on values of the in vivo turnover half-lives of …

Interindividual variability in cytochrome P450 3A4 (CYP3A4) is believed to be largely
heritable; however, predictive genetic factors have remained scarce. Using a candidate …