The PFA-100 (platelet function analyzer) is a relatively new tool for the investigation of
primary hemostasis. This article reviews the history of the PFA-100 and details its clinical …

Summary Background: Closure time (CT), measured by platelet function analyzer (PFA‐
100®) device, is now available to the clinical laboratory as a possible alternative or …

Patients with liver diseases acquire complex alterations in their hemostatic system that may
lead to abnormalities in routine diagnostic test of hemostasis. Thrombocytopenia …

Cirrhosis of the liver is frequently accompanied by complex alterations in the hemostatic
system, resulting in a bleeding tendency. Although many hemostatic changes in liver …

Essentials• Patients with liver diseases may acquire substantial changes in all components
of hemostasis.• Hemostasis is in unstable balance due to simultaneous changes in pro‐and …

Haemostasis consists of a complicated sequence of events designed to prevent excessive
blood loss in case of vessel wall injury. The haemostatic system is in a delicate balance …

Abbreviations: α2β1-integrin= collagen receptor; ADP= adenosine diphosphate; BT=
bleeding time; CADP= collagen plus adenosine-5-diphosphate; CADP-CT= collagen …

Patients with cirrhosis can have abnormalities in laboratory tests reflecting changes in
primary haemostasis, including bleeding time, platelet function tests, markers of platelet …

Background The liver plays a central role in coagulation and fibrinolysis but is also closely
intertwined with the function and number of blood platelets. Aim To describe and integrate …

The liver is an essential player in the pathway of coagulation in both primary and secondary
haemostasis. Only von Willebrand factor is not synthetised by the liver, thus liver failure is …