I. Executive Summary Background The 5 years since the publication of the first International
Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed …

Knowledge of chronic rhinosinusitis (CRS) epidemiology may directly impact patient care:
aiding patient identification and establishing accurate diagnosis as well as informing …

Importance Chronic rhinosinusitis (CRS) is a broadly defined process that has previously
been used to describe many different sinonasal pathologic conditions from odontogenic …

Objective With the advent of new treatment options for Chronic Rhinosinusitis (CRS) comes
the ability for physicians to provide more individualized patient care. Physicians are now …

Background Chronic rhinosinusitis (CRS) is a complex disease that incorporates many
different conditions. Currently, primary CRS is considered a disease of broad airway …

Asthma is a prevalent inflammatory condition of the lower airways characterized by variable
and recurring symptoms, reversible airflow obstruction, and bronchial hyperresponsiveness …

Background Clinical studies on the effectiveness of omalizumab in patients with difficult-to-
treat chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma are scarce in China …

Eosinophil-mediated pathophysiology is tissue destructive and tissue altering with
proinflammatory, prothrombotic, and profibrotic effects. The distinctive morphology of an …

Chronic rhinosinusitis (CRS) is a diverse chronic inflammatory disease of the sinonasal
mucosa. CRS manifests itself in a variety of clinical and immunologic patterns. The …

Background Risk factors for the pathogenesis of chronic rhinosinusitis (CRS) remain largely
undetermined, which is likely due to the heterogeneity of the disease. White blood cell …