Clinically manifested resistance of bacteria to antibiotics has emerged as a global threat to
society and there is an urgent need for the development of novel classes of antibacterial …

The phosphonate class of natural products have received significant interests in the post-
genomic era due to the relative ease with which their biosynthetic genes may be identified …

Siderophores are synthesized by microbes to facilitate iron acquisition required for growth.
Catecholate, hydroxamate, and α-hydroxycarboxylate groups comprise well-established …

Reactive functional groups, such as N-nitrosamines, impart unique bioactivities to the
natural products in which they are found. Recent work has illuminated enzymatic N …

Historically, small molecules biosynthesised by bacteria have been an excellent source for
antibacterial drugs. Today, however, the rediscovery of known compounds is a significant …

Phosphonate natural products, with their potent inhibitory activity, have found widespread
use across multiple industries. Their success has inspired development of genome mining …

The C-diazeniumdiolate group in the amino acid graminine is emerging as a new
microbially produced Fe (III) coordinating ligand in siderophores, which is photoreactive …

Organophosphonates (Pns) are a unique class of natural products characterized by a highly
stable C–P bond. Pns exhibit a wide array of interesting structures as well as useful …

The biological formation of nitrogen–nitrogen (N–N) bonds represents intriguing reactions
that have attracted much attention in the past decade. This interest has led to an increasing …

Phosphonate natural products have a history of commercial success across numerous
industries due to their potent inhibition of metabolic processes. Over the past decade …