Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

Although plasminogen activator inhibitor 1 (PAI-1) is one of the primary regulators of the
fibrinolytic system, it also has dramatic effects on cell adhesion, detachment and migration …

The plasmin–antiplasmin system plays a key role in blood coagulation and fibrinolysis.
Plasmin and α 2-antiplasmin are primarily responsible for a controlled and regulated …

Blood–brain barrier (BBB) breakdown after stroke is linked to the up-regulation of
metalloproteinases (MMPs) and inflammation. This study examines the effects of …

The extracellular matrix (ECM) is a biological substrate composed of collagens,
proteoglycans and glycoproteins that ensures proper cell migration and adhesion and keeps …

Myocardial infarction and ischemic stroke are the most frequent causes of death or disability
worldwide. Due to their ability to dissolve blood clots, the thrombolytics are frequently used …

Cerebral vascular system can be divided into two categories: the macrovessels and
microvessels. The microvessels consist of arterioles, capillaries and venules. There are …

We demonstrate that tissue plasminogen activator (tPA) and its inhibitors contribute to
neurite outgrowth in the central nervous system (CNS) after treatment of stroke with …

Recent studies implicate extracellular proteases in synaptic plasticity, learning, and memory.
The data are especially strong for such serine proteases as thrombin, tissue plasminogen …

Neurons respond to numerous factors in their environment that influence their survival and
function during development and in the mature brain. Among these factors, the …