Wnt, a secreted glycoprotein, has an approximate molecular weight of 40 kDa, and it is a
cytokine involved in various biological phenomena including ontogeny, morphogenesis …

Osteoblasts, the bone-forming cells of the remodeling unit, are essential for growth and
maintenance of the skeleton. Clinical disorders of substrate availability (eg, diabetes …

Cartilage and the bordering subchondral bone form a functionally active regulatory interface
with a prominent role in osteoarthritis pathways. The Wnt and the OPG-RANKL-RANK …

The adult human skeleton is a multifunctional organ undergoing continuous remodeling.
Homeostasis of bone mass in a healthy adult requires an exquisite balance between bone …

Wnt signaling and its bone tissue–specific inhibitor sclerostin are key regulators of bone
homeostasis. The therapeutic potential of anti-sclerostin antibodies (Scl-Abs), for bone mass …

WNT s are extracellular proteins that activate different cell surface receptors linked to
canonical and noncanonical WNT signalling pathways. The Wnt genes were originally …

The Wnt signalling pathway is one of the central signalling pathways in bone development,
homeostasis and regulation of bone mineral density. It consists of numerous Wnt ligands …

Growth faltering under 5 years of age is unacceptably high worldwide, and even more
children, while not stunted, fail to reach their growth potential. The time between conception …

Wnt signaling executes an indispensable performance in osteoblast differentiation, bone
development, homeostasis, and remodeling. Wnt signals trigger the intracellular Wnt …

The mammalian/mechanistic target of rapamycin (mTOR) is a serine/threonine protein
kinase that integrates inputs from nutrients and growth factors to control many fundamental …