Microfluidic organ-chips and stem cell models in the fight against COVID-19

S Satta, SJ Rockwood, K Wang, S Wang… - Circulation …, 2023 - Am Heart Assoc
SARS-CoV-2, the virus underlying COVID-19, has now been recognized to cause
multiorgan disease with a systemic effect on the host. To effectively combat SARS-CoV-2 …

[HTML][HTML] Permittivity tensor imaging: modular label-free imaging of 3D dry mass and 3D orientation at high resolution

LH Yeh, IE Ivanov, T Chandler, JR Byrum, BB Chhun… - Nature …, 2024 - nature.com
The dry mass and the orientation of biomolecules can be imaged without a label by
measuring their permittivity tensor (PT), which describes how biomolecules affect the phase …

[HTML][HTML] The enzymes in COVID-19: a review

MHME Alves, LC Mahnke, TC Macedo… - Biochimie, 2022 - Elsevier
COVID-19 brought a scientific revolution since its emergence in Wuhan, China, in December
2019. Initially, the SARS-CoV-2 virus came to attention through its effects on the respiratory …

Identification of Human Host Substrates of the SARS-CoV-2 Mpro and PLpro Using Subtiligase N-Terminomics

SY Luo, EW Moussa, J Lopez-Orozco… - ACS Infectious …, 2023 - ACS Publications
The recent emergence of SARS-CoV-2 in the human population has caused a global
pandemic. The virus encodes two proteases, Mpro and PLpro, that are thought to play key …

Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin

PM Wydorski, J Osipiuk, BT Lanham, C Tesar… - Nature …, 2023 - nature.com
Abstract The Papain-like protease (PLpro) is a domain of a multi-functional, non-structural
protein 3 of coronaviruses. PLpro cleaves viral polyproteins and posttranslational …

Mass spectrometric assays reveal discrepancies in inhibition profiles for the SARS‐CoV‐2 papain‐like protease

L Brewitz, JJAG Kamps, P Lukacik… - …, 2022 - Wiley Online Library
The two SARS‐CoV‐2 proteases, ie the main protease (Mpro) and the papain‐like protease
(PLpro), which hydrolyze the viral polypeptide chain giving functional non‐structural …

In silico screening of inhibitors of the Venezuelan Equine Encephalitis Virus nonstructural protein 2 cysteine protease

X Hu, E Morazzani, JR Compton, M Harmon… - Viruses, 2023 - mdpi.com
The Venezuelan equine encephalitis virus (VEEV) nonstructural protein 2 (nsP2) cysteine
protease (EC 3.4. 22. B79) is essential for viral replication. High throughput in silico/in vitro …

SARS-CoV-2 Main protease targets host selenoproteins and glutathione biosynthesis for knockdown via proteolysis, potentially disrupting the thioredoxin and …

IA Gallardo, DA Todd, ST Lima, JR Chekan, NH Chiu… - Antioxidants, 2023 - mdpi.com
Associations between dietary selenium status and the clinical outcome of many viral
infections, including SARS-CoV-2, are well established. Multiple independent studies have …

Studies on the selectivity of the SARS-CoV-2 papain-like protease reveal the importance of the P2′ proline of the viral polyprotein

HTH Chan, L Brewitz, P Lukacik… - RSC Chemical …, 2024 - pubs.rsc.org
The SARS-CoV-2 papain-like protease (PLpro) is an antiviral drug target that catalyzes the
hydrolysis of the viral polyproteins pp1a/1ab, so releasing the non-structural proteins (nsps) …

In situ endothelial SARS-CoV-2 presence and PROS1 plasma levels alteration in SARS-CoV-2-associated coagulopathies

M Baroni, S Beltrami, G Schiuma, P Ferraresi, S Rizzo… - Life, 2024 - mdpi.com
Background: Coagulation decompensation is one of the complications most frequently
encountered in COVID-19 patients with a poor prognosis or long-COVID syndrome, possibly …