One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-
activated protein kinase (AMPK), which is activated when intracellular ATP production …

AMP-activated protein kinase (AMPK) is a sensor of energy status that maintains cellular
energy homeostasis. It arose very early during eukaryotic evolution, and its ancestral role …

In the past decade, studies of the human tumour suppressor LKB1 have uncovered a novel
signalling pathway that links cell metabolism to growth control and cell polarity. LKB1 …

The SNF1/AMP-activated protein kinase (AMPK) family maintains the balance between ATP
production and consumption in all eukaryotic cells. The kinases are heterotrimers that …

After years of extensive scientific discovery much has been learned about the networks that
regulate epithelial homeostasis. Loss of expression or functional activity of cell adhesion …

AMP-activated protein kinase (AMPK) is a highly conserved sensor of cellular energy status
found in all eukaryotic cells. AMPK is activated by stimuli that increase the cellular AMP/ATP …

We recently demonstrated that the LKB1 tumour suppressor kinase, in complex with the
pseudokinase STRAD and the scaffolding protein MO25, phosphorylates and activates AMP …

Germline mutations in LKB1, TSC2, or PTEN tumor suppressor genes result in
hamartomatous syndromes with shared tumor biological features. The recent observations …

Little is known about metabolic regulation in stem cells and how this modulates tissue
regeneration or tumour suppression. We studied the Lkb1 tumour suppressor and its …

The par genes were discovered in genetic screens for regulators of cytoplasmic partitioning
in the early embryo of C. elegans, and encode six different proteins required for asymmetric …