Abstract Purpose of Review The purpose of this article is to review the current understanding
of inflammatory processes on bone, including direct impacts of inflammatory factors on bone …

Objectives Fracture is a common injury after a traumatic event. The efficacy and safety of non-
steroidal anti-inflammatory drugs (NSAIDs) to treat acute pain related to fractures is not well …

Bone pain typically occurs immediately following skeletal damage with mechanical distortion
or rupture of nociceptive fibres. The pain mechanism is also associated with chronic pain …

In the context of an ageing population, the demographic sands of trauma are shifting.
Increasingly, trauma units are serving older adults who have sustained injuries in low …

Introduction Nonsteroidal anti-inflammatory drugs (NSAIDs) may potentially delay or cause
non-union of fractures by inhibiting prostaglandin synthesis. However, studies have shown …

Acute pain is a common reason for seeking emergency care. 1 The prevalence of both acute
and chronic pain in older adults seeking care in the emergency department (ED) is likely …

Nonsteroidal anti‐inflammatory drugs (NSAIDs) are a valuable class of medications for
orthopedic surgeons and often play a pivotal role in pain control. However, there are many …

Non-steroidal anti-inflammatory drugs (NSAIDs) are crucial components of multimodal
analgesia for musculoskeletal injuries, targeting cyclooxygenase (COX) enzymes (COX-1 …

Surgical management of fractures has advanced with the incorporation of advanced
technology, surgical techniques, and regenerative therapies, but delayed bone healing …

While recent studies showed that macrophages are critical for bone fracture healing, and
lack of M2 macrophages have been implicated in models of delayed union, functional roles …