Mitochondrial impairment: A common motif in neuropsychiatric presentation? The link to the tryptophan–kynurenine metabolic system

M Tanaka, Á Szabó, E Spekker, H Polyák, F Tóth… - Cells, 2022 - mdpi.com
Nearly half a century has passed since the discovery of cytoplasmic inheritance of human
chloramphenicol resistance. The inheritance was then revealed to take place maternally by …

Endoplasmic reticulum–mitochondrial contactology: structure and signaling functions

G Csordás, D Weaver, G Hajnóczky - Trends in cell biology, 2018 - cell.com
Interorganellar contacts are increasingly recognized as central to the control of cellular
behavior. These contacts, which typically involve a small fraction of the endomembrane …

Mitochondria as central regulators of neural stem cell fate and cognitive function

M Khacho, R Harris, RS Slack - Nature Reviews Neuroscience, 2019 - nature.com
Emerging evidence now indicates that mitochondria are central regulators of neural stem
cell (NSC) fate decisions and are crucial for both neurodevelopment and adult …

The interplay of dopamine metabolism abnormalities and mitochondrial defects in the pathogenesis of schizophrenia

H Xu, F Yang - Translational psychiatry, 2022 - nature.com
Dopamine (DA) is a major monoamine neurotransmitter in the brain and has essential roles
in higher functions of the brain. Malfunctions of dopaminergic signaling have been …

The role of mitochondria in mood disorders: from physiology to pathophysiology and to treatment

A Giménez-Palomo, S Dodd, G Anmella… - Frontiers in …, 2021 - frontiersin.org
Mitochondria are cellular organelles involved in several biological processes, especially in
energy production. Several studies have found a relationship between mitochondrial …

Miro proteins coordinate microtubule‐and actin‐dependent mitochondrial transport and distribution

G López‐Doménech, C Covill‐Cooke… - The EMBO …, 2018 - embopress.org
In the current model of mitochondrial trafficking, Miro1 and Miro2 Rho‐GTP ases regulate
mitochondrial transport along microtubules by linking mitochondria to kinesin and dynein …

[HTML][HTML] Emerging roles of brain metabolism in cognitive impairment and neuropsychiatric disorders

IM Morella, R Brambilla, L Morè - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
Here we discuss the role of diverse environmental manipulations affecting cognition with
special regard to psychiatric conditions. We present evidence supporting a direct causal …

[HTML][HTML] Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?

KJ De Vos, M Hafezparast - Neurobiology of disease, 2017 - Elsevier
Intracellular trafficking of cargoes is an essential process to maintain the structure and
function of all mammalian cell types, but especially of neurons because of their extreme …

[HTML][HTML] Role of the mitochondrial contact site and cristae organizing system in membrane architecture and dynamics

H Rampelt, RM Zerbes, M van der Laan… - Biochimica et Biophysica …, 2017 - Elsevier
The elaborate membrane architecture of mitochondria is a prerequisite for efficient
respiration and ATP generation. The cristae membranes, invaginations of the inner …

Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery

S Modi, G López-Doménech, EF Halff… - Nature …, 2019 - nature.com
Abstract Mitochondrial Rho (Miro) GTPases localize to the outer mitochondrial membrane
and are essential machinery for the regulated trafficking of mitochondria to defined …