Pravastatin, proton-pump inhibitors, metformin, micronutrients, and biologics: new horizons for the prevention or treatment of preeclampsia

S Tong, J Tu'uhevaha, R Hastie, F Brownfoot… - American journal of …, 2022 - Elsevier
There has been increasing research momentum to identify new therapeutic agents for the
prevention or treatment of preeclampsia, drugs that can affect the underlying disease …

Atypical preeclampsia before 20 weeks of gestation—a systematic review

J Modzelewski, I Siarkowska, J Pajurek-Dudek… - International Journal of …, 2023 - mdpi.com
This systematic review was conducted to gather evidence of preeclampsia occurring before
the 20th week of gestation, additionally considering the role of PLGF and sFlt-1 in the …

Aspirin for the prevention and treatment of pre‐eclampsia: A matter of COX‐1 and/or COX‐2 inhibition?

KM Mirabito Colafella, RI Neuman… - Basic & clinical …, 2020 - Wiley Online Library
Since the 1970s, we have known that aspirin can reduce the risk of pre‐eclampsia.
However, the underlying mechanisms explaining this risk reduction are poorly understood …

Systematic review with meta‐analysis: the risks of proton pump inhibitors during pregnancy

CM Li, A Zhernakova, L Engstrand… - Alimentary …, 2020 - Wiley Online Library
Background There have been safety concerns considering long‐term proton pump inhibitor
(PPI) use, also during pregnancy. Aims To assess the risk of adverse neonatal outcomes …

The pathophysiological, genetic, and hormonal changes in preeclampsia: A systematic review of the molecular mechanisms

YT Chiang, KM Seow, KH Chen - International Journal of Molecular …, 2024 - mdpi.com
Preeclampsia, a serious complication of pregnancy, involves intricate molecular and cellular
mechanisms. Fetal microchimerism, where fetal cells persist within maternal tissues and in …

Population-based cohort study: proton pump inhibitor use during pregnancy in Sweden and the risk of maternal and neonatal adverse events

EM Breddels, J Simin, R Fornes, H Lilja Engstrand… - BMC medicine, 2022 - Springer
Background Approximately half of all women suffer from heartburn at some stage during
pregnancy. The most effective treatment is proton pump inhibitors, but the safety of use …

Novel therapeutic and diagnostic approaches for preeclampsia

M Vatish, VR Powys, AS Cerdeira - Current Opinion in …, 2023 - journals.lww.com
We provide an updated framework of the current approaches to define and diagnose
preeclampsia. Disease modifying therapies (in particular, targeting the angiogenic pathway) …

Programming of renal development and chronic disease in adult life

ER Lumbers, Y Kandasamy, SJ Delforce… - Frontiers in …, 2020 - frontiersin.org
Chronic kidney disease (CKD) can have an insidious onset because there is a gradual
decline in nephron number throughout life. There may be no overt symptoms of renal …

Review of recent evidence on the management of heartburn in pregnant and breastfeeding women

RAR Ali, J Hassan, LJ Egan - BMC gastroenterology, 2022 - Springer
Gastroesophageal reflux disease (GERD) is one the most common medical complaints in
pregnant women. Some women continue to experience GERD symptoms after delivery …

Modulation of preeclampsia by the cholinergic anti-inflammatory pathway: Therapeutic perspectives

AM Wedn, HM El-Bassossy, AH Eid… - Biochemical …, 2021 - Elsevier
The cholinergic anti-inflammatory pathway (CAP) is vital for the orchestration of the immune
and inflammatory responses under normal and challenged conditions. Over the past two …