Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) belong to a superfamily of
nuclear receptors called steroid hormone receptors, which, upon binding ligand, dimerize …

RA is characterized by a systemic inflammatory state, in which immune cells and soluble
mediators play a crucial role. These inflammatory processes resemble those in other chronic …

The “holy grail” of cancer therapy is to identify and exploit genetic elements and signal
transduction pathways capable of selectively destroying tumor cells without eliciting harmful …

The melanoma differentiation-associated gene-7 (mda-7; approved gene symbol IL24) is a
tumor suppressor gene whose expression induces selective apoptosis in tumor cells. To …

The mda-7 gene (approved gene symbol IL24) is a novel tumor suppressor gene with tumor-
apoptotic and immune-activating properties. We completed a Phase I dose-escalation …

“Differentiation therapy” provides a unique and potentially effective, less toxic treatment
paradigm for cancer. Moreover, combining “differentiation therapy” with molecular …

Apoptosis and autophagy play seminal roles in maintaining organ homeostasis. Apoptosis
represents canonical type I programmed cell death. Autophagy is viewed as pro-survival …

Melanoma differentiation associated gene-7 (mda-7) was cloned using subtraction
hybridization from terminally differentiated human melanoma cells. Based on structural and …

A noteworthy aspect of melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-
24) as a cancer therapeutic is its ability to selectively kill cancer cells without harming normal …

Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) is a unique
member of the IL-10 gene family that displays nearly ubiquitous cancer-specific toxicity, with …