Common variable immunodeficiency (CVID) is a heterogenous disease category created to
distinguish late‐onset antibody deficiencies from early‐onset diseases like …

Introduction: Lipodystrophy is a heterogeneous group of rare diseases characterized by
various degrees of fat loss which leads to serious morbidity due to metabolic abnormalities …

Lipodystrophy is a heterogeneous group of disorders characterized by lack of body fat in
characteristic patterns, which can be genetic or acquired. Lipodystrophy is associated with …

Background Although chiefly a B-lymphocyte disorder, several research groups have
identified common variable immunodeficiency (CVID) subjects with numeric and/or …

Innate lymphoid cells type 3 (ILC3s) are the first line sentinels at the mucous tissues, where
they contribute to the homeostatic immune response in a major way. Also, they have been …

Objective To update the reader on recently proposed common variable immune deficiency
(CVID) diagnostic criteria, newly uncovered CVID pathobiology, freshly identified CVID …

The identification of genetic disorders associated with dysregulated immunity has upended
the notion that germline pathogenic variants in immune genes universally result in …

CTLA4-deficient patients exhibit profound humoral immune dysfunction, yet the basis for the
B cell defect is not known. We observed a marked reduction in transitional to follicular B cell …

Purpose CTLA4 deficiency is an inborn error of immunity (IEI) due to heterozygosity for
germline loss-of-function variants of the CTLA4 gene located on chromosome 2q33. 2 …

Innate lymphoid cells (ILCs) were found to be developmentally related to natural killer (NK)
cells. In humans, they are mostly located in “barrier” tissues where they contribute to innate …