Under physiological conditions, adenosine triphosphate (ATP) is present at low levels in the
extracellular milieu, being massively released by stressed or dying cells. Once outside the …

P2X7 is a transmembrane receptor expressed in multiple cell types including neurons,
dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of …

Cancer is still one of the world's most pressing health-care challenges, leading to a high
number of deaths worldwide. Immunotherapy is a new developing therapy that boosts …

Breast cancer is currently the most common cancer and the leading cause of cancer death
among women worldwide. Advanced breast cancer is prone to metastasis, and there is …

Large amounts of adenosine triphosphate (ATP), a natural P2X7 receptor activator, are
released during colorectal carcinogenesis. P2X7 receptor activation regulates the activity of …

The occurrence and development of tumors is a multi-factor, multi-step, multi-gene
pathological process, and its treatment has been the most difficult problem in the field of …

Highlights•Tumor bearing P2X7R null mice show increased and better performing
Treg.•Chemotactic gradient established by P2X7R ligands favors tumor infiltration by …

Alternative splicing (AS) tremendously increases the use of genetic information by
generating protein isoforms that differ in protein–protein interactions, catalytic activity and/or …

Background Osteosarcoma is the most common malignant tumor in bone and its prognosis
has reached a plateau in the past few decades. Recently, metabolic reprogramming has …

Cancer comprises a collection of diseases that occur in almost any tissue and it is
characterized by an abnormal and uncontrolled cell growth that results in tumor formation …