The biomolecular corona of lipid nanoparticles for gene therapy

V Francia, RM Schiffelers, PR Cullis… - Bioconjugate …, 2020 - ACS Publications
Gene therapy holds great potential for treating almost any disease by gene silencing, protein
expression, or gene correction. To efficiently deliver the nucleic acid payload to its target …

Lipid-based drug delivery systems in cancer therapy: what is available and what is yet to come

P Yingchoncharoen, DS Kalinowski… - Pharmacological …, 2016 - ASPET
Cancer is a leading cause of death in many countries around the world. However, the
efficacy of current standard treatments for a variety of cancers is suboptimal. First, most …

Nanoparticle uptake: the phagocyte problem

HH Gustafson, D Holt-Casper, DW Grainger… - Nano today, 2015 - Elsevier
Phagocytes are key cellular participants determining important aspects of host exposure to
nanomaterials, initiating clearance, biodistribution and the tenuous balance between host …

Immunological and toxicological considerations for the design of liposomes

CT Inglut, AJ Sorrin, T Kuruppu, S Vig, J Cicalo… - Nanomaterials, 2020 - mdpi.com
Liposomes hold great potential as gene and drug delivery vehicles due to their
biocompatibility and modular properties, coupled with the major advantage of attenuating …

Toxicology of nanoparticles in drug delivery

S Sharma, R Parveen, BP Chatterji - Current pathobiology reports, 2021 - Springer
Nanoparticles have revolutionized biomedicine especially in the field of drug delivery due to
their intriguing properties such as systemic stability, level of solubility, and target site …

Recent advancements in polymer/liposome assembly for drug delivery: From surface modifications to hybrid vesicles

V De Leo, F Milano, A Agostiano, L Catucci - Polymers, 2021 - mdpi.com
Liposomes are consolidated and attractive biomimetic nanocarriers widely used in the field
of drug delivery. The structural versatility of liposomes has been exploited for the …

Poly (ethylene glycol) in drug delivery: pros and cons as well as potential alternatives

K Knop, R Hoogenboom, D Fischer… - Angewandte chemie …, 2010 - Wiley Online Library
Abstract Poly (ethylene glycol)(PEG) is the most used polymer and also the gold standard for
stealth polymers in the emerging field of polymer‐based drug delivery. The properties that …

Challenges in development of nanoparticle-based therapeutics

N Desai - The AAPS journal, 2012 - Springer
In recent years, nanotechnology has been increasingly applied to the area of drug
development. Nanoparticle-based therapeutics can confer the ability to overcome biological …

Complement activation-related pseudoallergy: a stress reaction in blood triggered by nanomedicines and biologicals

J Szebeni - Molecular immunology, 2014 - Elsevier
Intravenous injection of a variety of nanotechnology enhanced (liposomal, micellar, polymer-
conjugated) and protein-based (antibodies, enzymes) drugs can lead to hypersensitivity …

Liposome and immune system interplay: Challenges and potentials

F Zahednezhad, M Saadat, H Valizadeh… - Journal of Controlled …, 2019 - Elsevier
Liposome as a revolutionizing carrier, has exhibited favorable aspects in drug delivery.
However, there are numerous challenges affecting its effectiveness. Hypersensitivity …