Since ancient times, natural medicines have had paramount importance in bolstering
biotherapeutics to treat various diseases. The World Health Organization (WHO) revealed …

Currently, the demand for more reliable drug screening devices has made scientists and
researchers develop novel potential approaches to offer an alternative to animal studies …

Glioblastoma is the most malignant primary brain tumor and is still in need of effective
medical treatment. We isolated patient-derived glioblastoma cells showing high GD2 …

Among the different hallmarks of cancer, deregulation of cellular metabolism turned out to be
an essential mechanism in promoting cancer resistance and progression. The pyruvate …

The limitations of traditional two-dimensional (2D) cultures and animal testing, when it
comes to precisely foreseeing the toxicity and clinical effectiveness of potential drug …

Cell culture is one of the most core and fundamental techniques employed in the fields of
biology and medicine. At present, although the two‐dimensional cell culture method is …

The establishment of clinically relevant models for tumor metastasis and drug testing is a
major challenge in cancer research. Here we report a physiologically relevant assay …

Successful preclinical drug testing relies in part on data generated using in vitro cell culture
models that recapitulate the structure and function of tumours and other tissues in vivo. The …

From the development of self-aggregating, scaffold-free multicellular spheroids to the
inclusion of scaffold systems, 3D models have progressively increased in complexity to …

All multicellular organisms rely on intercellular communication networks to coordinate
physiological functions. As members of a dynamic social network, each cell receives …