Functional pancreatic islet beta cells are essential to ensure glucose homeostasis across
species from zebrafish to humans. These cells show significant heterogeneity, and emerging …

The pancreatic islet vasculature comprises microvascular endothelial cells surrounded by
mural cells (pericytes). Both cell types support the islet by providing (1) a conduit for delivery …

While inflammation is beneficial for insulin secretion during homeostasis, its transformation
adversely affects β-cells and contributes to diabetes. However, the regulation of islet …

Precise matching of energy substrate delivery to local metabolic needs is essential for the
health and function of all tissues. Here, we outline a mechanistic framework for …

Diabetes is not only an endocrine but also a vascular disease. Vascular defects are usually
seen as consequence of diabetes. However, at the level of the pancreatic islet, vascular …

Histopathological heterogeneity in the human pancreas is well documented; however,
functional evidence at the tissue level is scarce. Herein, we investigate in situ glucose …

The COVID-19 pandemic has profoundly affected human health, yet the mechanisms
underlying its impact on metabolic and vascular systems remain incompletely understood …

Aims Sulfatide is a chaperone for insulin manufacturing in beta cells. Here we explore
whether the blood glucose values normally could be associated with this sphingolipid and …

It is crucial to study the human pancreas to understand the pathophysiological mechanisms
associated with type 1 (T1D) and 2 diabetes (T2D) as well as the pancreas endocrine and …

It is crucial to study the human pancreas to understand the pathophysiological mechanisms
associated with type 1 (T1D) and 2 diabetes (T2D) as well as the pancreas endocrine and …