Noise and variability are fundamental companions to ion channels and synapses and thus
inescapable elements of brain function. The overriding unresolved issue is to what extent …

We consider multi-class systems of interacting nonlinear Hawkes processes modeling
several large families of neurons and study their mean field limits. As the total number of …

Highlights•Balanced networks are widespread in the brain, yet their role in the spinal cord is
unclear.•Respiratory and lumbar circuits show signs of balanced activity.•Network motifs are …

When spinal circuits generate rhythmic movements it is important that the neuronal activity
remains within stable bounds to avoid saturation and to preserve responsiveness. Here, we …

The spinal cord contains a diverse array of interneurons that govern motor output.
Traditionally, models of spinal circuits have emphasized the role of inhibition in enforcing …

The purpose of the study was to expand a model of motor unit recruitment and rate coding to
simulate the adjustments that occur during a fatiguing contraction. The major new …

Stochastic leaky integrate-and-fire models are popular due to their simplicity and statistical
tractability. They have been widely applied to gain understanding of the underlying …

New Findings What is the central question of this study? How long can humans sustain
motor unit discharge during a voluntary contraction? What is the main finding and its …

The purpose of this study was to record the discharge characteristics of tibialis anterior motor
units over a range of target forces and to import these data, along with previously reported …

Direct measurements of synaptic inhibition (I) and excitation (E) to spinal motoneurons can
provide an important insight into the organization of premotor networks. Such measurements …