Emerging therapeutics targeting cellular stress pathways to mitigate end-organ damage in type 1 diabetes

TA Addissouky - Avicenna Journal of Medical Biochemistry, 2024 - ajmb.umsha.ac.ir
Abstract Type 1 diabetes (T1D) is an autoimmune disease characterized by insulin
deficiency and impaired glucose regulation. While daily insulin therapy is life-saving, many …

Alzheimer's Disease: Models and Molecular Mechanisms Informing Disease and Treatments

KL Nystuen, SM McNamee, M Akula, KM Holton… - Bioengineering, 2024 - mdpi.com
Alzheimer's Disease (AD) is a complex neurodegenerative disease resulting in progressive
loss of memory, language and motor abilities caused by cortical and hippocampal …

[HTML][HTML] Glucose variability in people with type 1 diabetes: associations with body weight, body composition, and insulin sensitivity

JF Semenova, AY Yushin, AI Korbut, VV Klimontov - Biomedicines, 2024 - mdpi.com
The prevalence of overweight and obesity increases in people with type 1 diabetes (T1D).
However, the impact of fat accumulation on glucose dynamics in T1D is poorly understood …

Diabetes-induced muscle wasting: molecular mechanisms and promising therapeutic targets

R Qiao, J Guo, C Zhang, S Wang, J Fang… - Critical Reviews in …, 2024 - Taylor & Francis
Diabetes has become a serious public health crisis, presenting significant challenges to
individuals worldwide. As the largest organ in the human body, skeletal muscle is a …

[HTML][HTML] Decoding the Significance of Alpha Cell Function in the Pathophysiology of Type 1 Diabetes

J Carroll, J Chen, R Mittal, JRN Lemos, M Mittal… - Cells, 2024 - mdpi.com
Alpha cells in the pancreas, traditionally known for their role in secreting glucagon to
regulate blood glucose levels, are gaining recognition for their involvement in the …

[HTML][HTML] Targeting IL-12 family cytokines: A potential strategy for type 1 and type 2 diabetes mellitus

J Luo, T Ning, X Li, T Jiang, S Tan, D Ma - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Diabetes is a common metabolic disease characterized by an imbalance in blood glucose
levels. The pathogenesis of diabetes involves the essential role of cytokines, particularly the …

The Impact of Metabolic Memory on Immune Profile in Young Patients with Uncomplicated Type 1 Diabetes

J Neubauer-Geryk, M Wielicka, M Myśliwiec… - International Journal of …, 2024 - mdpi.com
Metabolic memory refers to the long-term effects of achieving early glycemic control and the
adverse implications of high blood glucose levels, including the development and …

[HTML][HTML] Serum and urinary levels of MIF, CD74, DDT and CXCR4 among patients with type 1 diabetes mellitus, type 2 diabetes and healthy individuals: Implications …

K Mangano, A Diamantopoulos, NG Vallianou… - Metabolism Open, 2024 - Elsevier
Background Macrophage migration inhibitory factor (MIF) is a highly conserved cytokine with
pleiotropic properties, mainly pro-inflammatory. MIF seems to exert its pro-inflammatory …

IL-20RA is Associated with the Risk of Diabetic Microangiopathy: A Bidirectional Mendelian Randomization Analysis and Clinical Validation

J Li, H Yang, T Wang, N Ruan, Y Lin… - … Metabolic Syndrome and …, 2024 - Taylor & Francis
Objective Studies have demonstrated a link between chronic inflammatory responses and
diabetic microangiopathy, which include diabetic nephropathy, diabetic retinopathy, and …

[HTML][HTML] Маркеры воспаления низкой интенсивности и уровни цитокинов в сыворотке крови у больных сахарным диабетом 1 типа: ассоциации со временем в …

ВВ Климонтов, КР Мавлянова, ЮФ Семёнова… - Сахарный …, 2024 - cyberleninka.ru
ОБОСНОВАНИЕ. Повышенная вариабельность уровня глюкозы (ВГ) признана
фактором риска сосудистых осложнений при диабете. Предполагают, что …