Oxidative stress: a suitable therapeutic target for optic nerve diseases?

F Buonfiglio, EW Böhm, N Pfeiffer, A Gericke - Antioxidants, 2023 - mdpi.com
Optic nerve disorders encompass a wide spectrum of conditions characterized by the loss of
retinal ganglion cells (RGCs) and subsequent degeneration of the optic nerve. The etiology …

Anthocyanins: molecular aspects on their neuroprotective activity

CA Zaa, ÁJ Marcelo, Z An, JL Medina-Franco… - Biomolecules, 2023 - mdpi.com
Anthocyanins are a type of flavonoids that give plants and fruits their vibrant colors. They are
known for their potent antioxidant properties and have been linked to various health …

Clinical significance of micronutrient supplementation in critically ill COVID-19 patients with severe ARDS

Q Notz, J Herrmann, T Schlesinger, P Helmer… - Nutrients, 2021 - mdpi.com
The interplay between inflammation and oxidative stress is a vicious circle, potentially
resulting in organ damage. Essential micronutrients such as selenium (Se) and zinc (Zn) …

Dietary polyphenols, microbiome, and multiple sclerosis: From molecular anti-inflammatory and neuroprotective mechanisms to clinical evidence

G La Rosa, MS Lonardo, N Cacciapuoti… - International Journal of …, 2023 - mdpi.com
Multiple sclerosis (MS) is a multifactorial, immune-mediated disease caused by complex
gene-environment interactions. Dietary factors modulating the inflammatory status through …

Mitochondria, a key target in amyotrophic lateral sclerosis pathogenesis

EC Genin, M Abou-Ali, V Paquis-Flucklinger - Genes, 2023 - mdpi.com
Mitochondrial dysfunction occurs in numerous neurodegenerative diseases, particularly
amyotrophic lateral sclerosis (ALS), where it contributes to motor neuron (MN) death. Of all …

Selective PPAR-Delta/PPAR-gamma activation improves cognition in a model of Alzheimer's disease

I Steinke, M Govindarajulu, PD Pinky, J Bloemer, S Yoo… - Cells, 2023 - mdpi.com
Background: The continuously increasing association of Alzheimer's disease (AD) with
increased mortality rates indicates an unmet medical need and the critical need for …

CoQ10 and Mitochondrial Dysfunction in Alzheimer's Disease

Z Fišar, J Hroudová - Antioxidants, 2024 - mdpi.com
The progress in understanding the pathogenesis and treatment of Alzheimer's disease (AD)
is based on the recognition of the primary causes of the disease, which can be deduced …

Mitochondria Dysfunction and Neuroinflammation in Neurodegeneration: Who Comes First?

C Peggion, T Calì, M Brini - Antioxidants, 2024 - mdpi.com
Neurodegenerative diseases (NDs) encompass an assorted array of disorders such as
Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, each …

Ethanolic Extract of Polygonum minus Protects Differentiated Human Neuroblastoma Cells (SH-SY5Y) against H2O2-Induced Oxidative Stress

NH Sayuti, N Zulkefli, JK Tan, N Saad, SN Baharum… - Molecules, 2023 - mdpi.com
Neuronal models are an important tool in neuroscientific research. Hydrogen peroxide
(H2O2), a major risk factor of neuronal oxidative stress, initiates a cascade of neuronal cell …

Dietary Polyphenols Decrease Chemokine Release by Human Primary Astrocytes Responding to Pro-Inflammatory Cytokines

M Grabarczyk, D Ksiazek-Winiarek, A Glabinski… - Pharmaceutics, 2023 - mdpi.com
Astrocytes are considered to be the dominant cell fraction of the central nervous system.
They play a supportive and protective role towards neurons, and regulate inflammatory …