Approximately one-tenth of the general population exhibit adrenal cortical nodules, and the
incidence has increased. Afflicted patients display a multifaceted symptomatology …

Adrenocortical carcinoma is a rare malignancy with an annual worldwide incidence of 1–2
cases per 1 million and a 5-year survival rate of< 60%. Although adrenocortical carcinoma is …

The adrenal glands synthesize and release essential steroid hormones such as cortisol and
aldosterone, but many aspects of human adrenal gland development are not well …

The diagnosis of low-grade adrenal cortical carcinoma (ACC) confined to the adrenal gland
can be challenging. Although there are diagnostic and prognostic molecular tests for ACC …

Careful morphological evaluation forms the basis of the workup of an adrenal cortical
neoplasm. However, the adoption of immunohistochemical biomarkers has added …

Unraveling molecular mechanisms that regulate tumor development and proliferation is of
the utmost importance in the quest to decrease the high mortality rate of adrenocortical …

DNA methylation profiling has been suggested a reliable technique to distinguish between
benign and malignant adrenocortical tumors, a process which with current diagnostic …

Background The prediction of human gene–abnormal phenotype associations is a
fundamental step toward the discovery of novel genes associated with human disorders …

Recent studies have revealed that pseudogene transcripts can function as competing
endogenous RNAs, and thereby can also contribute to cancer when dysregulated. We have …

Adrenal incidentalomas are the most frequent human neoplasms. Recent genomic
investigations on functional adrenocortical tumors have demonstrated that somatic …