Molecular mechanisms underlying the renal protective effects of coenzyme Q10 in acute kidney injury

S Zhao, W Wu, J Liao, X Zhang, M Shen, X Li… - Cellular & Molecular …, 2022 - Springer
Abstract Coenzyme Q10 (CoQ10), an endogenous antioxidant, has been reported frequently
to exert an outstanding protective effect on multiple organ injury, including acute kidney …

Plant‐derived agents for counteracting cisplatin‐induced nephrotoxicity

S Ojha, B Venkataraman, A Kurdi… - Oxidative medicine …, 2016 - Wiley Online Library
Cisplatin (CSP) is a chemotherapeutic agent commonly used to treat a variety of
malignancies. The major setback with CSP treatment is that its clinical efficacy is …

Catechins: therapeutic perspectives in COVID-19-associated acute kidney injury

LRL Diniz, HA Elshabrawy, MTS Souza, ABS Duarte… - Molecules, 2021 - mdpi.com
Data obtained from several intensive care units around the world have provided substantial
evidence of the strong association between impairment of the renal function and in-hospital …

Combined treatment of epigallocatechin gallate and Coenzyme Q10 attenuates cisplatin-induced nephrotoxicity via suppression of oxidative/nitrosative stress …

S Fatima, N Al-Mohaimeed, Y Al-Shaikh, P Tyagi… - Food and Chemical …, 2016 - Elsevier
Cisplatin (CP), a platinum based anticancer drug is used as one of the first-line therapy for
the treatment of different types of solid tumors. However, CP-induced side effects …

AH2S Donor GYY4137 Exacerbates Cisplatin‐Induced Nephrotoxicity in Mice

M Liu, Z Jia, Y Sun, A Zhang… - Mediators of inflammation, 2016 - Wiley Online Library
Accumulating evidence demonstrated that hydrogen sulfide (H2S) is highly involved in
inflammation, oxidative stress, and apoptosis and contributes to the pathogenesis of kidney …

Protection of coenzyme Q10 against contrast-induced acute kidney injury in male diabetic rats

SMF Couto, CD da Fonseca, M Watanabe… - Diabetology & Metabolic …, 2021 - Springer
Background Diabetes mellitus (DM) is a major risk factor for contrast-induced acute kidney
injury (CI-AKI). DM and CI-AKI result in oxidative damage and inflammation that can be …

The critical role of epigallocatechin gallate in regulating mitochondrial metabolism

W Shi, L Li, Y Ding, K Yang, Z Chen, X Fan… - Future Medicinal …, 2018 - Taylor & Francis
Epigallocatechin gallate (EGCG), one of polyphenols isolated from green tea, exhibits
biology-benefiting effects with minimum severe adverse. EGCG is known to be a …

Epigallocatechin gallate and coenzyme Q10 attenuate cisplatin‐induced hepatotoxicity in rats via targeting mitochondrial stress and apoptosis

S Fatima, N Suhail, M Alrashed, S Wasi… - … of Biochemical and …, 2021 - Wiley Online Library
Despite the extensive use of cisplatin (CP) as a chemotherapeutic agent, its clinical use is
often restricted by undesirable side effects, such as toxicity to normal tissues. The aim of this …

A new update for radiocontrast-induced nephropathy aggravated with glycerol in rats: the protective potential of epigallocatechin-3-gallate

SS Palabiyik, B Dincer, E Cadirci, I Cinar… - Renal …, 2017 - Taylor & Francis
Contrast media (CM) is known to have nephrotoxic adverse effects. Epigallocatechin-3-
gallate (EGCG) is the most abundant and active catechin in green tea, and has strong …

Coenzyme Q10 protects renal proximal tubule cells against nicotine-induced apoptosis through induction of p66shc-dependent antioxidant responses

I Arany, A Carter, S Hall, T Fulop, M Dixit - Apoptosis, 2017 - Springer
Chronic nicotine exposure (via smoking, E-cigarettes) increases oxidative stress in the
kidney that sensitizes it to additional injury in experimental models and in the renal patient …