[HTML][HTML] Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention

LM Butler, Y Perone, J Dehairs, LE Lupien… - Advanced drug delivery …, 2020 - Elsevier
With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

Lipid droplets: platforms with multiple functions in cancer hallmarks

ALS Cruz, EA Barreto, NPB Fazolini, JPB Viola… - Cell death & …, 2020 - nature.com
Lipid droplets (also known as lipid bodies) are lipid-rich, cytoplasmic organelles that play
important roles in cell signaling, lipid metabolism, membrane trafficking, and the production …

Alterations of lipid metabolism in cancer: implications in prognosis and treatment

LP Fernández, M Gomez de Cedron… - Frontiers in …, 2020 - frontiersin.org
Cancer remains the second leading cause of mortality worldwide. In the course of this
multistage and multifactorial disease, a set of alterations takes place, with genetic and …

The endocannabinoid system: A target for cancer treatment

C Laezza, C Pagano, G Navarra, O Pastorino… - International journal of …, 2020 - mdpi.com
In recent years, the endocannabinoid system has received great interest as a potential
therapeutic target in numerous pathological conditions. Cannabinoids have shown an …

A guide to targeting the endocannabinoid system in drug design

A Stasiulewicz, K Znajdek, M Grudzień… - International journal of …, 2020 - mdpi.com
The endocannabinoid system (ECS) is one of the most crucial systems in the human
organism, exhibiting multi-purpose regulatory character. It is engaged in a vast array of …

The endocannabinoid system as a target in cancer diseases: are we there yet?

E Moreno, M Cavic, A Krivokuca, V Casadó… - Frontiers in …, 2019 - frontiersin.org
The endocannabinoid system (ECS) has been placed in the anti-cancer spotlight in the last
decade. The immense data load published on its dual role in both tumorigenesis and …

Cannabinoids as anticancer therapeutic agents

O Kovalchuk, I Kovalchuk - Cell Cycle, 2020 - Taylor & Francis
The recent announcement of marijuana legalization in Canada spiked many discussions
about potential health benefits of Cannabis sativa. Cannabinoids are active chemical …

Molecular mechanism of cannabinoids in cancer progression

C Pagano, G Navarra, L Coppola, M Bifulco… - International Journal of …, 2021 - mdpi.com
Cannabinoids are a family of heterogeneous compounds that mostly interact with receptors
eliciting several physiological effects both in the central and peripheral nervous systems and …

Enhanced endocannabinoid tone as a potential target of pharmacotherapy

M Toczek, B Malinowska - Life sciences, 2018 - Elsevier
The endocannabinoid system is up-regulated in numerous pathophysiological states such
as inflammatory, neurodegenerative, gastrointestinal, metabolic and cardiovascular …

Monoacylglycerol lipase (MAGL) as a promising therapeutic target

A Gil-Ordóñez, M Martín-Fontecha… - Biochemical …, 2018 - Elsevier
Monoacylglycerol lipase (MAGL) has been characterized as the main enzyme responsible
for the inactivation of the most abundant brain endocannabinoid, 2-arachidonoylglycerol (2 …