Computational studies on carboxylate-assisted C–H activation and functionalization at
group 8–10 transition metal centers are reviewed. This Review is organized by metal and …

The transition metal-catalyzed transformation of otherwise inert C–H bonds into substituted
alkenes offers a versatile tool for the synthesis of value added olefinic molecules. Recent …

The site-selective formation of carbonrcarbon bonds through direct functionalizations of
otherwise unreactive carbonrhydrogen bonds constitutes an economically attractive strategy …

Functionalizing traditionally inert carbon–hydrogen bonds represents a powerful
transformation in organic synthesis, providing new entries to valuable structural motifs and …

The area of transition‐metal‐catalyzed direct arylation through cleavage of C H bonds has
undergone rapid development in recent years, and is becoming an increasingly viable …

The concerted metalation− deprotonation mechanism predicts relative reactivity and
regioselectivity for a diverse set of arenes spanning the entire spectrum of known palladium …

The cleavage of aromatic C–H bonds promoted by a metal and an intramolecular base has
been described over 50 years ago. Herein, discussion of selected mechanistic studies of this …

The abundance of the biaryl structural motif in natural products, in biologically active
molecules and in materials chemistry has positioned aryl–aryl (Ar–Ar) bond formation high …

We have developed a new site-selective Cu (II)-catalyzed C− H bond functionalization
process that can selectively arylate indoles at either the C3 or C2 position under mild …

Metal-catalyzed coupling reactions of aryl electrophiles with organometallics and with
olefins serve as unusually effective tools for forming new carbon− carbon bonds. By 1998 …