In 1999, Genes and Immunity published a systematic review and on-line database of
cytokine gene polymorphism in human disease, 1 and in 2001 a supplement to the review …

Cytokines play an important role in the regulation of normal immune function. In recent years
cytokines and their receptors have been shown to be highly polymorphic. Polymorphisms in …

Donor genomics influence graft events: The effect of donor polymorphisms on acute
rejection and chronic allograft nephropathy. Background Organs procured from deceased …

Tissue attenuates to injury by the effects of heme oxygenase (HO)-1. The induction of HO-1
expression is modulated by a (GT) n dinucleotide polymorphism in the promoter of the gene …

IL-6 in vitro production, as well as the serum/plasma concentration of the cytokine, increase
with age. In the present investigation, a total of 62 individuals (31 males and 31 females) …

Of all kidney transplants, half are still lost in the first decade after transplantation. Here, using
genetics, we probed whether interleukin 6 (IL‐6) could be a target in kidney transplantation …

Background. Pretransplantation identification of patients at an increased risk for adverse
events would allow more individualized treatment strategies possibly improving long-term …

Background. Acute allograft rejection remains an important cause of morbidity after kidney
transplantation, and has been shown to be a crucial determinant of long-term graft function …

Background. Cytokines such as tumor necrosis factor (TNF)-α and interleukin (IL)-10 play
significant roles in the inflammatory and immune responses that mediate allograft rejection …

It has been demonstrated that many cytokine genes [eg tumour necrosis factor α (TNF‐α)
and interleukin 10 (IL‐10)] show polymorphisms which may affect gene transcription …