Brain transcriptomics reveal the activation of neuroinflammation pathways during acute Orientia tsutsugamushi infection in mice

Y Liang, Aditi, F Onyoni, H Wang, C Gonzales… - Frontiers in …, 2023 - frontiersin.org
Scrub typhus, an acute febrile illness caused by Orientia tsutsugamushi (Ot), is prevalent in
endemic areas with one million new cases annually. Clinical observations suggest central …

Comprehensive review on cardiac manifestation of scrub typhus

BP Sivasubramanian, AHS Abdul Khader… - Frontiers in Tropical …, 2024 - frontiersin.org
Scrub typhus, a zoonotic disease caused by Orientia tsutsugamushi and transmitted by
chiggers, predominantly affects the Asia-Pacific region. Complications of Scrub Typhus …

Trem2/Syk/PI3K axis contributes to the host protection against Toxoplasma gondii-induced adverse pregnancy outcomes via modulating decidual macrophages

Q Wang, Y Cao, S Ye, M Ding, W Ge, Y Liang… - PLoS …, 2024 - journals.plos.org
Decidual macrophages residing at the maternal-fetal interface have been recognized as
pivotal factors for maintaining normal pregnancy; however, they are also key target cells of …

Lack of the IFN-γ signal leads to lethal Orientia tsutsugamushi infection in mice with skin eschar lesions

Y Liang, H Wang, K Sun, J Sun, L Soong - PLoS pathogens, 2024 - journals.plos.org
Scrub typhus is an acute febrile disease due to Orientia tsutsugamushi (Ot) infection and can
be life-threatening with organ failure, hemorrhage, and fatality. Yet, little is known as to how …

Differential cellular immune responses against Orientia tsutsugamushi Karp and Gilliam strains following acute infection in mice

JD Thiriot, Y Liang, C Gonzales, J Sun… - PLoS neglected …, 2023 - journals.plos.org
Scrub typhus is a leading cause of febrile illness in endemic countries due to infection with
Orientia tsutsugamushi (Ot), a seriously understudied intracellular bacterium. Pulmonary …

Concatenated ScaA and TSA56 Surface Antigen Sequences Reflect Genome-Scale Phylogeny of Orientia tsutsugamushi: An Analysis Including Two Genomes from …

NT Minahan, TY Yen, YLL Guo, PY Shu, KH Tsai - Pathogens, 2024 - mdpi.com
Orientia tsutsugamushi is an obligate intracellular bacterium associated with trombiculid
mites and is the causative agent of scrub typhus, a life-threatening febrile disease. Strain …