Tissue Engineering Approaches in the Design of Healthy and Pathological In Vitro Tissue Models
S Caddeo, M Boffito, S Sartori - Frontiers in bioengineering and …, 2017 - frontiersin.org
In the tissue engineering (TE) paradigm, engineering and life sciences tools are combined
to develop bioartificial substitutes for organs and tissues, which can in turn be applied in …
to develop bioartificial substitutes for organs and tissues, which can in turn be applied in …
Engineered in vitro disease models
The ultimate goal of most biomedical research is to gain greater insight into mechanisms of
human disease or to develop new and improved therapies or diagnostics. Although great …
human disease or to develop new and improved therapies or diagnostics. Although great …
Electrical and mechanical stimulation of cardiac cells and tissue constructs
The field of cardiac tissue engineering has made significant strides over the last few
decades, highlighted by the development of human cell derived constructs that have shown …
decades, highlighted by the development of human cell derived constructs that have shown …
The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes
MS Nielsen, CJM van Opbergen… - Physiological …, 2023 - journals.physiology.org
The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …
mechanical and electrical junctions. Although described in some detail by light microscopy …
[HTML][HTML] Central role for GSK3β in the pathogenesis of arrhythmogenic cardiomyopathy
SP Chelko, A Asimaki, P Andersen, D Bedja… - JCI insight, 2016 - ncbi.nlm.nih.gov
Arrhythmogenic cardiomyopathy (ACM) is characterized by redistribution of junctional
proteins, arrhythmias, and progressive myocardial injury. We previously reported that …
proteins, arrhythmias, and progressive myocardial injury. We previously reported that …
Cyclic AMP sensor EPAC proteins and their role in cardiovascular function and disease
F Lezoualc'h, L Fazal, M Laudette, C Conte - Circulation research, 2016 - Am Heart Assoc
cAMP is a universal second messenger that plays central roles in cardiovascular regulation
influencing gene expression, cell morphology, and function. A crucial step toward a better …
influencing gene expression, cell morphology, and function. A crucial step toward a better …
Micropattern width dependent sarcomere development in human ESC-derived cardiomyocytes
MR Salick, BN Napiwocki, J Sha, GT Knight… - Biomaterials, 2014 - Elsevier
In this study, human embryonic stem cell-derived cardiomyocytes were seeded onto
controlled two-dimensional micropatterned features, and an improvement in sarcomere …
controlled two-dimensional micropatterned features, and an improvement in sarcomere …
GJA1-20k arranges actin to guide Cx43 delivery to cardiac intercalated discs
WA Basheer, S Xiao, I Epifantseva, Y Fu… - Circulation …, 2017 - Am Heart Assoc
Rationale: Delivery of Cx43 (connexin 43) to the intercalated disc is a continuous and rapid
process critical for intercellular coupling. By a pathway of targeted delivery involving …
process critical for intercellular coupling. By a pathway of targeted delivery involving …
Mimicking human pathophysiology in organ‐on‐chip devices
Convergence of life sciences, engineering, and basic sciences has opened new horizons for
biologically inspired innovations, and a considerable number of organ‐on‐a‐chip platforms …
biologically inspired innovations, and a considerable number of organ‐on‐a‐chip platforms …
Silicon nanowire-induced maturation of cardiomyocytes derived from human induced pluripotent stem cells
The current inability to derive mature cardiomyocytes from human pluripotent stem cells has
been the limiting step for transitioning this powerful technology into clinical therapies. To …
been the limiting step for transitioning this powerful technology into clinical therapies. To …