Oxidative cyclizations are important transformations that occur widely during natural product
biosynthesis. The transformations from acyclic precursors to cyclized products can afford …

Iron-containing enzymes are one of Nature's main means of effecting key biological
transformations. The mononuclear non-heme iron oxygenases and oxidases have received …

Mononuclear non-heme ferrous iron dependent oxygenases and oxidases constitute an
extended enzyme family that catalyze a wide range of oxidation reactions. The largest …

Antimicrobials are useful compounds intended to eradicate or stop the growth of harmful
microorganisms. The sustained increase in the rates of antimicrobial resistance (AMR) …

Fosfomycin is a clinically utilized, highly effective antibiotic, which is active against
methicillin-and vancomycin-resistant pathogens. Here we report the cloning and …

Aeruginosins represent a group of peptide metabolites isolated from various cyanobacterial
genera and from marine sponges that potently inhibit different types of serine proteases …

Anthraquinone-fused enediynes (AQEs) are renowned for their distinctive molecular
architecture, reactive enediyne warhead, and potent anticancer activity. Although the first …

(1R, 2S)-Epoxypropylphosphonic acid, also known as fosfomycin, is a clinically utilized,
highly effective antibiotic that has low toxicity and is effective against methicillin and …

Urinary tract infections (UTIs) and male genital infections are amongst the most prevalent
infections. A prudent antibiotic policy therefore has a large impact on society. The clinical …

Background The members of cupin superfamily exhibit large variations in their sequences,
functions, organization of domains, quaternary associations and the nature of bound metal …