Fluorinated alternatives to long-chain perfluoroalkyl carboxylic acids (PFCAs), perfluoroalkane sulfonic acids (PFSAs) and their potential precursors

Z Wang, IT Cousins, M Scheringer… - Environment …, 2013 - Elsevier
Since 2000 there has been an on-going industrial transition to replace long-chain
perfluoroalkyl carboxylic acids (PFCAs), perfluoroalkane sulfonic acids (PFSAs) and their …

[HTML][HTML] Chemicals inhaled from spray cleaning and disinfection products and their respiratory effects. A comprehensive review

PA Clausen, M Frederiksen, CS Sejbæk… - International journal of …, 2020 - Elsevier
Spray cleaning and disinfection products have been associated with adverse respiratory
effects in professional cleaners and among residents doing domestic cleaning. This review …

Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale

S Halappanavar, S Van Den Brule, P Nymark… - Particle and Fibre …, 2020 - Springer
Toxicity testing and regulation of advanced materials at the nanoscale, ie nanosafety, is
challenged by the growing number of nanomaterials and their property variants requiring …

Evaluation of exposure concentrations used in assessing manufactured nanomaterial environmental hazards: are they relevant?

PA Holden, F Klaessig, RF Turco… - … science & technology, 2014 - ACS Publications
Manufactured nanomaterials (MNMs) are increasingly produced and used in consumer
goods, yet our knowledge regarding their environmental risks is limited. Environmental risks …

Organotropic drug delivery: Synthetic nanoparticles and extracellular vesicles

S Busatto, A Pham, A Suh, S Shapiro… - Biomedical …, 2019 - Springer
Most clinically approved drugs (primarily small molecules or antibodies) are rapidly cleared
from circulation and distribute throughout the body. As a consequence, only a small portion …

[HTML][HTML] An adverse outcome pathway for lung surfactant function inhibition leading to decreased lung function

E Da Silva, U Vogel, KS Hougaard, J Pérez-Gil… - Current research in …, 2021 - Elsevier
Inhaled substances, such as consumer products, chemicals at the workplace, and
nanoparticles, can affect the lung function in several ways. In this paper, we explore the …

Critical aspects of sample handling for direct nanoparticle analysis and analytical challenges using asymmetric field flow fractionation in a multi-detector approach

A Ulrich, S Losert, N Bendixen, A Al-Kattan… - Journal of Analytical …, 2012 - pubs.rsc.org
The analysis of engineered nanomaterials (ENMs), especially engineered nanoparticles
(ENPs), is a fast growing analytical research field. New trends in plasma spectrometry such …

Effects of Astragalus and Codonopsis pilosula polysaccharides on alveolar macrophage phagocytosis and inflammation in chronic obstructive pulmonary disease …

X Chu, XJ Liu, JM Qiu, XL Zeng, HR Bao… - Environmental Toxicology …, 2016 - Elsevier
Astragalus and Codonopsis pilosula are used for their immunomodulatory and anti-
inflammatory effects. Here, we investigated the effects of Astragalus polysaccharides (APS) …

Usefulness of intratracheal instillation studies for estimating nanoparticle-induced pulmonary toxicity

Y Morimoto, H Izumi, Y Yoshiura, K Fujishima… - International journal of …, 2016 - mdpi.com
Inhalation studies are the gold standard for the estimation of the harmful effects of respirable
chemical substances, while there is limited evidence of the harmful effects of chemical …

[HTML][HTML] Analytical and toxicological aspects of nanomaterials in different product groups: Challenges and opportunities

HR Tschiche, FS Bierkandt, O Creutzenberg, V Fessard… - NanoImpact, 2022 - Elsevier
The widespread integration of engineered nanomaterials into consumer and industrial
products creates new challenges and requires innovative approaches in terms of design …