Chasing bacterial chassis for metabolic engineering: a perspective review from classical to non‐traditional microorganisms
The last few years have witnessed an unprecedented increase in the number of novel
bacterial species that hold potential to be used for metabolic engineering. Historically …
bacterial species that hold potential to be used for metabolic engineering. Historically …
Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis
S Ehrt, D Schnappinger, KY Rhee - Nature Reviews Microbiology, 2018 - nature.com
Metabolism was once relegated to the supply of energy and biosynthetic precursors, but it
has now become clear that it is a specific mediator of nearly all physiological processes. In …
has now become clear that it is a specific mediator of nearly all physiological processes. In …
[HTML][HTML] Fundamental behaviors emerge from simulations of a living minimal cell
ZR Thornburg, DM Bianchi, TA Brier, BR Gilbert… - Cell, 2022 - cell.com
We present a whole-cell fully dynamical kinetic model (WCM) of JCVI-syn3A, a minimal cell
with a reduced genome of 493 genes that has retained few regulatory proteins or small …
with a reduced genome of 493 genes that has retained few regulatory proteins or small …
[HTML][HTML] A whole-cell computational model predicts phenotype from genotype
JR Karr, JC Sanghvi, DN Macklin, MV Gutschow… - Cell, 2012 - cell.com
Understanding how complex phenotypes arise from individual molecules and their
interactions is a primary challenge in biology that computational approaches are poised to …
interactions is a primary challenge in biology that computational approaches are poised to …
High-throughput generation, optimization and analysis of genome-scale metabolic models
Genome-scale metabolic models have proven to be valuable for predicting organism
phenotypes from genotypes. Yet efforts to develop new models are failing to keep pace with …
phenotypes from genotypes. Yet efforts to develop new models are failing to keep pace with …
Bacterial genome size and gene functional diversity negatively correlate with taxonomic diversity along a pH gradient
Bacterial gene repertoires reflect adaptive strategies, contribute to ecosystem functioning
and are limited by genome size. However, gene functional diversity does not necessarily …
and are limited by genome size. However, gene functional diversity does not necessarily …
Genomic diversity, lifestyles and evolutionary origins of DPANN archaea
Archaea—a primary domain of life besides Bacteria—have for a long time been regarded as
peculiar organisms that play marginal roles in biogeochemical cycles. However, this picture …
peculiar organisms that play marginal roles in biogeochemical cycles. However, this picture …
Essential metabolism for a minimal cell
M Breuer, TM Earnest, C Merryman, KS Wise, L Sun… - Elife, 2019 - elifesciences.org
JCVI-syn3A, a robust minimal cell with a 543 kbp genome and 493 genes, provides a
versatile platform to study the basics of life. Using the vast amount of experimental …
versatile platform to study the basics of life. Using the vast amount of experimental …
Evolutionary microbial genomics: insights into bacterial host adaptation
C Toft, SGE Andersson - Nature Reviews Genetics, 2010 - nature.com
Host-adapted bacteria include mutualists and pathogens of animals, plants and insects.
Their study is therefore important for biotechnology, biodiversity and human health. The …
Their study is therefore important for biotechnology, biodiversity and human health. The …
Proteome organization in a genome-reduced bacterium
The genome of Mycoplasma pneumoniae is among the smallest found in self-replicating
organisms. To study the basic principles of bacterial proteome organization, we used …
organisms. To study the basic principles of bacterial proteome organization, we used …