Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells
VR Silva, LS Santos, RB Dias… - Cancer …, 2021 - Wiley Online Library
Colorectal cancer (CRC) represents the third most commonly diagnosed cancer and the
second leading cause of cancer death worldwide. The modern concept of cancer biology …
second leading cause of cancer death worldwide. The modern concept of cancer biology …
Epithelial-mesenchymal transition and MicroRNAs in colorectal cancer chemoresistance to FOLFOX
The FOLFOX scheme, based on the association of 5-fluorouracil and oxaliplatin, is the most
frequently indicated chemotherapy scheme for patients diagnosed with metastatic colorectal …
frequently indicated chemotherapy scheme for patients diagnosed with metastatic colorectal …
Ensemble of kernel ridge regression-based small molecule–miRNA association prediction in human disease
MicroRNAs (miRNAs) play crucial roles in human disease and can be targeted by small
molecule (SM) drugs according to numerous studies, which shows that identifying SM …
molecule (SM) drugs according to numerous studies, which shows that identifying SM …
Predicting potential small molecule–miRNA associations utilizing truncated schatten p-norm
S Wang, T Liu, C Ren, W Wu, Z Zhao… - Briefings in …, 2023 - academic.oup.com
MicroRNAs (miRNAs) have significant implications in diverse human diseases and have
proven to be effectively targeted by small molecules (SMs) for therapeutic interventions …
proven to be effectively targeted by small molecules (SMs) for therapeutic interventions …
Dual-network collaborative matrix factorization for predicting small molecule-miRNA associations
MicroRNAs (miRNAs) play crucial roles in multiple biological processes and human
diseases and can be considered as therapeutic targets of small molecules (SMs). Because …
diseases and can be considered as therapeutic targets of small molecules (SMs). Because …
SNMFSMMA: using symmetric nonnegative matrix factorization and Kronecker regularized least squares to predict potential small molecule-microRNA association
Accumulating studies have shown that microRNAs (miRNAs) could be used as targets of
small-molecule (SM) drugs to treat diseases. In recent years, researchers have proposed …
small-molecule (SM) drugs to treat diseases. In recent years, researchers have proposed …
Colorectal cancer stem cells and targeted agents
H Zhao, R Han, Z Wang, J Xian, X Bai - Pharmaceutics, 2023 - mdpi.com
Since their discovery, cancer stem cells have become a hot topic in cancer therapy research.
These cells possess stem cell-like self-renewal and differentiation capacities and are …
These cells possess stem cell-like self-renewal and differentiation capacities and are …
Cellular mechanisms accounting for the refractoriness of colorectal carcinoma to pharmacological treatment
Simple Summary Colorectal cancer (CRC) causes a high number (more than 800,000) of
deaths worldwide each year. Better methods for early diagnosis and the development of …
deaths worldwide each year. Better methods for early diagnosis and the development of …
MicroRNAs in cancer therapy: Their involvement in oxaliplatin sensitivity/resistance of cancer cells with a focus on colorectal cancer
The resistance of cancer cells into chemotherapy has restricted the efficiency of anti-tumor
drugs. Oxaliplatin (OX) being an anti-tumor agent/drug is extensively used in the treatment of …
drugs. Oxaliplatin (OX) being an anti-tumor agent/drug is extensively used in the treatment of …
4‑Acetylantroquinonol B enhances cell death and inhibits autophagy by downregulating the PI3K/Akt/MDR1 pathway in gemcitabine‑resistant pancreatic cancer cells
YY Chen, SY Chen, TJ Li, TW Lin… - Oncology …, 2022 - spandidos-publications.com
Gemcitabine (GEM) is a typical chemotherapeutic drug used to treat pancreatic cancer, but
GEM resistance develops within weeks after chemotherapy. Hence, the development of a …
GEM resistance develops within weeks after chemotherapy. Hence, the development of a …