The centenary of insulin discovery represents an important opportunity to transform diabetes
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …

Abstract Background and aims Metabolic Syndrome (MS) prevalence is increasing
worldwide in line with the growing prevalence of obesity. The underlying mechanism of MS …

Background Insulin resistance is a determining factor in the pathophysiology of type 2
diabetes mellitus (T2DM). Exercise is known to improve insulin resistance, but a systematic …

The molecular changes that occur with aging are not well understood,,–. Here, we
performed longitudinal and deep multiomics profiling of 106 healthy individuals from 29 to …

We present Bisque, a tool for estimating cell type proportions in bulk expression. Bisque
implements a regression-based approach that utilizes single-cell RNA-seq (scRNA-seq) or …

Time-restricted eating (TRE) has become a popular strategy to treat obesity. TRE involves
confining the eating window to 4–10 h per day and fasting for the remaining hours (14–20 h …

Insulin resistance (IR), a metabolic risk factor, is linked to the pathogenetic mechanism of
primary hypertension. Detecting IR in the patients with hypertension will help to predict and …

Abstract Purpose of Review We review the underlying mechanisms and potential benefits of
intermittent fasting (IF) from animal models and recent clinical trials. Recent Findings …

Objective The present study aimed to validate homeostasis model assessment of insulin
resistance (HOMA-IR) in relation to the insulin tolerance test (ITT) in a model of insulin …

Objective This study compared the effects of alternate‐day fasting (ADF) with those of daily
calorie restriction (CR) on body weight and glucoregulatory factors in adults with overweight …